In vitro gamete differentiation from pluripotent stem cells as a promising therapy for infertility
| Autor: | Aurélie Mouka, Gérard Tachdjian, Joëlle Dupont, Loïc Drévillon, Lucie Tosca |
|---|---|
| Přispěvatelé: | Service d'Histologie Embryologie Cytogénétique, Hôpitaux Universitaires Paris Sud, Université Paris-Sud - Paris 11 (UP11), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Pluripotent Stem Cells 0301 basic medicine [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] Somatic cell Biology Gametogenesis 03 medical and health sciences medicine cellule souche Animals Humans Induced pluripotent stem cell différenciation de gonades Genetics Cell Biology Hematology infertilité Embryonic stem cell Cell biology stem cell 030104 developmental biology medicine.anatomical_structure Infertility Gamete Female Stem cell Reprogramming Germ cell Stem Cell Transplantation Developmental Biology |
| Zdroj: | Stem Cells and Development Stem Cells and Development, Mary Ann Liebert, 2016, 25 (7), pp.509-521. ⟨10.1089/scd.2015.0230⟩ |
| ISSN: | 1547-3287 |
| DOI: | 10.1089/scd.2015.0230⟩ |
| Popis: | Generation of gametes derived in vitro from pluripotent stem cells holds promising prospects for future reproductive applications. Indeed, it provides information on molecular and cellular mechanisms underlying germ cell (GC) development and could offer a new potential treatment for infertility. Great progress has been made in derivation of gametes from embryonic stem cells, despite ethical issues. Induced pluripotent stem cells (iPSCs) technology allows the reprogramming of a differentiated somatic cell, possibly emanating from the patient, into a pluripotent state. With the emergence of iPSCs, several studies created primordial GC stage to mature gamete-like cells in vitro in mice and humans. Recent findings in GC derivation suggest that in mice, functional gametes can be generated in vitro. This strengthens the idea that it might be possible in the future to generate functional human sperm and oocytes from pluripotent stem cells in culture. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|