TREM-1 isoforms in bacterial infections: to immune modulation and beyond
| Autor: | Helioswilton Sales-Campos, Marcelle Silva-Sales, Amanda de Oliveira Matos, Pedro Henrique Dos Santos Dantas |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Gene isoform 030106 microbiology Context (language use) Inflammation Applied Microbiology and Biotechnology Microbiology Sepsis 03 medical and health sciences medicine Animals Humans Protein Isoforms Receptor Innate immune system biology Bacteria Immunity General Medicine Bacterial Infections medicine.disease biology.organism_classification Triggering Receptor Expressed on Myeloid Cells-1 Biomarker 030104 developmental biology Immunology medicine.symptom Biomarkers |
| Zdroj: | Critical reviews in microbiology. 47(3) |
| ISSN: | 1549-7828 |
| Popis: | The triggering receptor expressed on myeloid cells 1 (TREM-1) is an innate immunity receptor associated with the amplification of inflammation in sterile and non-sterile inflammatory disorders. Since its first description, the two isoforms of the receptor, membrane and soluble (mTREM-1 and sTREM-1, respectively) have been largely explored in the immunopathogenesis of several bacterial diseases and sepsis. The role of the receptor in these scenarios seems to be at least partly dependent on the source/type of bacteria, host and context. As uncontrolled inflammation is a result of several bacterial infections, the inhibition of the receptor has been considered as a promising approach to treat such conditions. Further, sTREM-1 has been explored as a biomarker for diagnosis and/or prognosis of several bacterial diseases. Therefore, this review aims to provide an updated insight into how the receptor influences and is influenced by bacterial infections, highlighting the advances regarding the use/manipulation of TREM-1 isoforms in biomedical research and clinical practice. |
| Databáze: | OpenAIRE |
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