Temporal Changes of Protein Composition in Breast Milk of Chinese Urban Mothers and Impact of Caesarean Section Delivery
| Autor: | Yumei Zhang, Carlos Antonio De Castro, Michael Affolter, Ornella Avanti-Nigro, Rosemarie Jenni, Gerard Vinyes-Pares, Ai Zhao, Sagar K. Thakkar, Clara Lucia Garcia-Rodenas, Laurent Favre, Iris Roggero, Peiyu Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
breast milk proteins immune factors Chinese mothers CAESAREAN-section Time Factors Urban Population medicine.medical_treatment Physiology Lactation Medicine Nutrition and Dietetics biology Geography Lactoferrin Protein composition Milk Proteins medicine.anatomical_structure Female Antibody lcsh:Nutrition. Foods and food supply Adult medicine.medical_specialty China Serum albumin Immunoglobulins Mothers Enzyme-Linked Immunosorbent Assay lcsh:TX341-641 Breast milk Article Transforming Growth Factor beta1 03 medical and health sciences Transforming Growth Factor beta2 Internal medicine Humans Caesarean section Immune Factors 030109 nutrition & dietetics Milk Human business.industry Cesarean Section 030104 developmental biology Endocrinology Cross-Sectional Studies biology.protein business Food Science |
| Zdroj: | Nutrients; Volume 8; Issue 8; Pages: 504 Nutrients, Vol 8, Iss 8, p 504 (2016) Nutrients |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu8080504 |
| Popis: | Human breast milk (BM) protein composition may be impacted by lactation stage or factors related to geographical location. The present study aimed at assessing the temporal changes of BM major proteins over lactation stages and the impact of mode of delivery on immune factors, in a large cohort of urban mothers in China. 450 BM samples, collected in three Chinese cities, covering 8 months of lactation were analyzed for α-lactalbumin, lactoferrin, serum albumin, total caseins, immunoglobulins (IgA, IgM and IgG) and transforming growth factor (TGF) β1 and β2 content by microfluidic chip- or ELISA-based quantitative methods. Concentrations and changes over lactation were aligned with previous reports. α-lactalbumin, lactoferrin, IgA, IgM and TGF-β1 contents followed similar variations characterized by highest concentrations in early lactation that rapidly decreased before remaining stable up to end of lactation. TGF-β2 content displayed same early dynamics before increasing again. Total caseins followed a different pattern, showing initial increase before decreasing back to starting values. Serum albumin and IgG levels appeared stable throughout lactation. In conclusion, BM content in major proteins of urban mothers in China was comparable with previous studies carried out in other parts of the world and C-section delivery had only very limited impact on BM immune factors. |
| Databáze: | OpenAIRE |
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