Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt
| Autor: | Sarah K. Volkman, Lise Musset, Eric Legrand, Stanislaw J. Gabryszewski, Dyann F. Wirth, Béatrice Volney, Eli L. Moss, Stéphane Pelleau, Satish K. Dhingra, Daniel E. Neafsey, David A. Fidock, Jessica Casteras |
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| Přispěvatelé: | Laboratoire de Parasitologie, Centre National de Référence du Paludisme - Région Antilles-Guyane, Institut Pasteur de la Guyane - Réseau International des Instituts Pasteur - WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Broad Institute of MIT and Harvard, Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, Harvard School of Public Health, This work was supported by European Commission Grant REGPOT-CT-2011-285837-430 STRonGer (to S.P.), AgenceNationale de la Recherche Investissements d’Avenir Grant ANR-10-LABX-25-01(to S.P. and L.M.), NIH Grants R01AI50234 (to D.A.F.) and R01AI109023 (to D.A.F.),and the Institut de Veille Sanitaire. Sequencing was supported, in part, byNational Institute of Allergy and Infectious Diseases, NIH, Department ofHealth and Human Services Contract HHSN272200900018C., ANR-10-LABX-25-01/10-LABX-0025, CEBA, CEnter of the study of Biodiversity in Amazonia(2010), European Project : 285837, EC:FP7:REGPOT, FP7-REGPOT-2011-1, STRONGER(2011), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Columbia University College of Physicians and Surgeons, ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), European Project: 285837,EC:FP7:REGPOT,FP7-REGPOT-2011-1,STRONGER(2011), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Centre National de Référence du Paludisme - Laboratoire de parasitologie [Cayenne, Guyane française] (CNR) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
[SDV]Life Sciences [q-bio]
Protozoan Proteins Drug resistance MESH: Genetic Markers MESH: Genotype Chloroquine Genotype [SDV.SPEE] Life Sciences [q-bio]/Public Health and Epidemiology MESH: Quinolines/chemistry MESH: Inhibitory Concentration 50 Genetics education.field_of_study Multidisciplinary biology MESH: Chloroquine/therapeutic use Biological Sciences MESH: Malaria/drug therapy 3. Good health [SDV] Life Sciences [q-bio] [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology medicine.drug PfCRT MESH: Plasmodium falciparum/drug effects Population Plasmodium falciparum MESH: Plasmodium falciparum/genetics malaria MESH: Membrane Transport Proteins/genetics MESH: Phenotype Evolution Molecular Piperaquine evolution MESH: Evolution Molecular MESH: French Guiana parasitic diseases medicine Humans MESH: Genome [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology Allele education MESH: Prevalence MESH: Principal Component Analysis drug resistance MESH: Humans MESH: Alleles Membrane Transport Proteins MESH: Retrospective Studies MESH: Haplotypes biology.organism_classification medicine.disease MESH: Protozoan Proteins/genetics Mutation MESH: Mutation MESH: Drug Resistance/genetics [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Malaria |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (37), pp.11672-7 Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (37), pp.11672-11677. ⟨10.1073/pnas.1507142112⟩ Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (37), pp.11672-11677. ⟨10.1073/pnas.1507142112⟩ |
| ISSN: | 0027-8424 1091-6490 |
| DOI: | 10.1073/pnas.1507142112⟩ |
| Popis: | Comment in : Fusion of field studies and the laboratory solves a puzzle in antimalarial resistance. [Proc Natl Acad Sci U S A. 2015]; International audience; In regions with high malaria endemicity, the withdrawal of chloroquine (CQ) as first-line treatment of Plasmodium falciparum infections has typically led to the restoration of CQ susceptibility through the reexpansion of the wild-type (WT) allele K76 of the chloroquine resistance transporter gene (pfcrt) at the expense of less fit mutant alleles carrying the CQ resistance (CQR) marker K76T. In low-transmission settings, such as South America, drug resistance mutations can attain 100% prevalence, thereby precluding the return of WT parasites after the complete removal of drug pressure. In French Guiana, despite the fixation of the K76T allele, the prevalence of CQR isolates progressively dropped from >90% to |
| Databáze: | OpenAIRE |
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