The methylenetetrahydrofolate reductase gene polymorphism in Koreans with coronary artery disease
| Autor: | Kyu-Yoon Hwang, Tai-Myung Choi, Chul-Hyun Kim, Won-Yong Shin, Sae-Yong Hong |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Hyperhomocysteinemia Genotype Homocysteine Coronary Disease Genetic determinism Pathogenesis Coronary artery disease chemistry.chemical_compound Asian People Internal medicine medicine Humans Methylenetetrahydrofolate Reductase (NADPH2) Aged Oxidoreductases Acting on CH-NH Group Donors Korea Polymorphism Genetic biology business.industry Middle Aged medicine.disease digestive system diseases Phenotype Endocrinology chemistry Methylenetetrahydrofolate reductase Mutation biology.protein Female Gene polymorphism Cardiology and Cardiovascular Medicine business |
| Zdroj: | International Journal of Cardiology. 78:13-17 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/s0167-5273(00)00431-9 |
| Popis: | Hyperhomocysteinemia is a known risk factor of cardiovascular diseases. Methylenetetrahydrofolate reductase (MTHFR), involved in folate-dependant metabolism, is associated with homocysteine levels. We studied the associations among MTHFR genotypes, coronary artery disease (CAD), and homocysteine levels in 85 patients with CAD and 152 healthy subjects. The MTHFR genotypes and plasma homocysteine levels were determined. No significant difference in mutation of the MTHFR gene between two groups was observed (P>0.05). While the homozygous mutant genotype (V/V) had the highest homocysteine levels compared to wild (A/A) and heterozygous mutant (A/V) genotypes, there were no significant differences in homocysteine levels among the MTHFR genotype groups. Homocysteine was significantly and inversely related to folate levels, the significant association in V/V genotype (beta coefficient=-1.954, P=0.04). Our data suggested that MTHFR polymorphism was not associated with homocysteine levels, implying no association between gene polymorphism and CAD in Koreans. |
| Databáze: | OpenAIRE |
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