Effects of 6-hydroxydopamine lesions of the nigrostriatal pathway on striatal serotonin innervation in adult rats
| Autor: | C.D. Marsden, S. B. Blunt, Tadashi Sawada, Peter Jenner, Yoshihiro Takeuchi |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Serotonin
Tyrosine 3-Monooxygenase Central nervous system Nigrostriatal pathway Biology Lesion Neural Pathways Basal ganglia medicine Animals Parkinson Disease Secondary Oxidopamine Molecular Biology Hydroxydopamine General Neuroscience Rats Inbred Strains Anatomy Immunohistochemistry Corpus Striatum Rats Substantia Nigra Disease Models Animal medicine.anatomical_structure nervous system Neurology (clinical) medicine.symptom Developmental Biology |
| Zdroj: | Brain Research. 562:301-305 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(91)90635-9 |
| Popis: | The effects of 6-hydroxydopamine lesions of the nigrostriatal pathway on striatal serotonin (5-HT) innervation have been examined using immunohistochemistry in adult rats. One day after lesioning, a large number of swollen and densely stained 5-HT-immunoreactive fibers appeared around the lesion which was almost completely void of 5-HT-immunoreactivity. Four weeks after lesioning, a significant reduction in 5-HT innervation density was verified in the ventral portion of the rostral neostriatum and in the caudal neostriatum of the lesioned side. Eight weeks after lesioning, a similar decrease in 5-HT innervation density was observed in the neostriatum on the lesioned side. Some aberrant 5-HT-immunoreactive fibers were found around the lesion of the nigrostriatal pathway. These results indicate that 6-hydroxydopamine lesions of the nigrostriatal bundle of adult rats induce a reduction in striatal serotonin innervation density as well as aberrant morphology of 5-HT-immunoreactive fibers around the lesion. |
| Databáze: | OpenAIRE |
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