Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans
| Autor: | Katherine J. Linder, Matthew F. Muldoon, Elizabeth C. Lawrence, Christopher E. Kline, Stephen B. Manuck, Serina A. Neumann, Robert E. Ferrell, Kimberly Sutton-Tyrrell, Catherine J. Shrader |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Carotid Artery Diseases Male Pathology medicine.medical_specialty Carotid Artery Common Carotid Intima-Media Thickness Risk Assessment White People Article Gene Frequency Predictive Value of Tests Risk Factors Polymorphism (computer science) Internal medicine Odds Ratio medicine Humans Genetic Predisposition to Disease Radiology Nuclear Medicine and imaging cardiovascular diseases Allele Genotyping Allele frequency Subclinical infection Polymorphism Genetic Symporters business.industry Middle Aged Pennsylvania Choline transporter Logistic Models Phenotype Endocrinology Intima-media thickness Asymptomatic Diseases cardiovascular system Female Choline transport Cardiology and Cardiovascular Medicine business |
| Zdroj: | The International Journal of Cardiovascular Imaging. 28:243-250 |
| ISSN: | 1573-0743 1569-5794 |
| DOI: | 10.1007/s10554-011-9831-4 |
| Popis: | Atherosclerosis is a heritable trait with little known about specific genetic influences on preclinical measures of plaque formation. Based on relations of parasympathetic-cholinergic function to atherosclerosis and to a choline transporter gene [CHT1 (G/T)] polymorphism, we investigated whether the same allelic variant predicts variation in carotid intima-media thickness (IMT) and plaque formation. Carotid IMT and plaque occurrence as well as genotyping for the CHT1 (G/T) variant were measured in a sample (N = 264) of generally healthy adults (age 30–55) of European ancestry. CHT1 GG homozygotes had greater IMT (P < 0.005) and plaque occurrence (P < 0.020) than T allele carriers. This is the first study showing polymorphic variation in the CHT1 gene to predict early, subclinical measures of carotid atherosclerosis which may aid in understanding cholinergic-vagal processes potentially underlying atherosclerotic risk. |
| Databáze: | OpenAIRE |
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