Effect of glycaemic control and age on low-density lipoprotein susceptibility to oxidation in diabetes mellitus type 1
| Autor: | F. Rengo, Francesco Cacciatore, Peter D. Reaven, Mario Condorelli, Claudio Napoli, Pasquale Abete, J. M. Hayden, A. Liguori, Domenico Bonaduce, Giuseppe Ambrosio |
|---|---|
| Přispěvatelé: | Liguori, A, Abete, P, Hayden, Jm, Cacciatore, F, Rengo, F, Ambrosio, G, Bonaduce, D, Condorelli, M, Reaven, Pd, Napoli, Claudio, Liguori, A., Abete, Pasquale, Hayden, J. M., Cacciatore, F., Rengo, F., Ambrosio, G., Bonaduce, D., Condorelli, M., Reaven, P. D., Napoli, C. |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Aging medicine.medical_treatment chemistry.chemical_compound Lipid oxidation Internal medicine Diabetes mellitus medicine Humans Apolipoproteins B Type 1 diabetes Lipid peroxide business.industry Insulin Vitamin E Age Factors Middle Aged medicine.disease Lipids Lipoproteins LDL Endocrinology Diabetes Mellitus Type 1 chemistry Low-density lipoprotein Apolipoprotein B-100 lipids (amino acids peptides and proteins) Female Disease Susceptibility Lipid Peroxidation Cardiology and Cardiovascular Medicine business Reactive Oxygen Species Oxidation-Reduction Lipoprotein Follow-Up Studies |
| Popis: | Background Although individuals with diabetes mellitus frequently have dyslipidaemias and high blood pressure, much of the increased risk for coronary heart disease is not explained by these and other classical risk factors. Thus, other less widely recognized risk factors, including increased susceptibility of low-density lipoprotein (LDL) to oxidation, might enhance vascular dysfunction and atherogenesis in diabetes. Aims We compared both the rate and extent of LDL oxidation ex vivo between 78 poorly controlled individuals with type 1 diabetes and 78 age- and sex-matched non-diabetic controls. We then initiated intensive insulin therapy for 3 months to determine the impact of improved glucose control on LDL composition and oxidation. Results Diabetic and non-diabetic individuals did not have significantly different body weights, dietary intake, blood pressure, renal function or plasma lipid levels. LDL composition was also similar in both groups. In contrast, vitamin E content in LDL was significantly lower in diabetic patients. Measures of LDL lipid oxidation, including conjugated diene, lipid peroxide and thiobarbituric acid reactive substances formation, as well as measures of LDL protein modification, were significantly greater in diabetic patients. Levels of hyperglycaemia correlated strongly with each measure of LDL lipid oxidation (r ranges from 0·60–0·81, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|