The PSMA-11-derived hybrid molecule PSMA-914 specifically identifies prostate cancer by preoperative PET/CT and intraoperative fluorescence imaging
| Autor: | Wael Y. Khoder, Juri Ruf, Sven Stadlbauer, C Gratzke, Mareike Roscher, Klaus Kopka, Ann-Christin Eder, Mohamed Aymen Omrane, Philipp T. Meyer, Matthias Eder, Cordula A. Jilg |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty PET-CT Fluorescence-lifetime imaging microscopy Nuclear Medicine Cardiology Imaging / Radiology Oncology Orthopedics business.industry Optical Imaging Prostatic Neoplasms General Medicine Prostate-Specific Antigen medicine.disease urologic and male genital diseases Prostate cancer Text mining Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Radiology business Image of the Month Edetic Acid |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging 48(2021)6, 2057-2058 European Journal of Nuclear Medicine and Molecular Imaging |
| Popis: | Resection of tumor tissue represents one of the standard curative treatment options for the clinical management of prostate cancer. However, intraoperative localization and precise delineation of malignant tissue from surrounding healthy structures still remain challenging. The development of PSMA-targeting hybrid molecules enabling the pre- and intraoperative detection of tumor tissue supported by both radioactivity (e.g., using DROP-IN technology) and fluorescence might help to overcome these limitations. Here, we report for the first time preoperative PET/CT imaging and subsequent fluorescence-guided surgery aided by a PSMA-11-derived peptidomimetic PSMA-targeting hybrid molecule. |
| Databáze: | OpenAIRE |
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