Vasorelaxant effects of macrocyclic bis(bibenzyls) from liverworts
| Autor: | Ikumi Koga, Aiko Saito, Toshio Kaneda, Toshihiro Hashimoto, Hiroki Okazaki, Kazumasa Zaima, Yoshinori Asakawa, Haruka Tamamoto, Hiroshi Morita |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Hepatophyta
Male Macrocyclic Compounds Stereochemistry Vasodilator Agents Clinical Biochemistry Pharmaceutical Science Pharmacognosy Nitric Oxide Marchantia paleacea Biochemistry Structure-Activity Relationship chemistry.chemical_compound Marchantia polymorpha Bibenzyls Drug Discovery medicine Animals Phenols Rats Wistar Molecular Biology Phenylephrine Aorta Cells Cultured biology Organic Chemistry Marchantia Endothelial Cells biology.organism_classification Rats Mechanism of action chemistry Molecular Medicine Calcium Channels medicine.symptom Cyclophane medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry. 19:4051-4056 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2011.05.019 |
| Popis: | Vasorelaxant effects of a series of bis(bibenzyls) from liverworts such as Marchantia polymorpha and Marchantia paleacea on rat aorta demonstrated that they relaxed phenylephrine (PE)-induced contractions, which may be mediated through the increased release of NO from endothelial cells as well as opening of K+ channels, and inhibition of Ca2+ influx through voltage-dependent Ca2+ channels (VDCs) and/or receptor-operated Ca2+ channels (ROCs). Structure–activity relationship based on their structures was discussed. The presence of two aromatic rings which can be connected through two atoms bridge spacer may play an important role for vasorelaxant effect. |
| Databáze: | OpenAIRE |
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