A pooled analysis of 12 cohort studies of dietary fat, cholesterol and egg intake and ovarian cancer
| Autor: | Arthur Schatzkin, Michael F. Leitzmann, Ellen Smit, Thomas E. Rohan, Anne Zeleniuch-Jacquotte, Anthony B. Miller, Walter C. Willett, Karen L. Koenig, W. Lawrence Beeson, Shumin M. Zhang, Stephanie A. Smith-Warner, Leo J. Schouten, Susan E. Hankinson, Julie A. Ross, David J. Hunter, Carmen Rodriguez, Julie E. Buring, R. Alexandra Goldbohm, Jo L. Freudenheim, Susanna C. Larsson, Jeanine M. Genkinger, Kristin E. Anderson, Donna Spiegelman, Marjorie L. McCullough, Gary E. Fraser, Graham A. Colditz, Alicja Wolk |
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| Přispěvatelé: | Epidemiologie, Humane Biologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, TNO Kwaliteit van Leven TNO Voeding |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
Calorie Fat intake Eggs Physiology Cohort Studies chemistry.chemical_compound Cancer risk Mathematical model Food intake Unsaturated fatty acid Priority journal Risk assessment Ovarian Neoplasms Statistical significance Cholesterol Oncology Health Saturated fatty acid Female Cohort analysis Cohort study Risk medicine.medical_specialty Histology Ovary cancer Food and Chemical Risk Analysis Major clinical study Cholesterol intake Ovarian cancer Internal medicine medicine Egg Humans business.industry Proportional hazards model Confidence interval Feeding Behavior medicine.disease Dietary Fats Diet Endocrinology chemistry Fat Relative risk North America Food Habits business Controlled study |
| Zdroj: | Cancer Causes & Control, 17(3), 273-285. Springer, Cham Cancer Causes and Control, 3, 17, 273-285 |
| ISSN: | 0957-5243 |
| Popis: | KEYWORDS - CLASSIFICATION: adverse effects;analysis;Boston;cancer epidemiology;Cholesterol;Cohort Studies;dietary modulation of cancer & cancer biomarkers;Dietary Fats;epidemiology;etiology;Eggs;Female;Food Habits;Humans;North America;Ovarian Neoplasms;Public Health;Research;Risk. Fat and cholesterol are theorized to promote ovarian carcinogenesis by increasing circulating estrogen levels. Although case-control studies have reported positive associations between total and saturated fat intake and ovarian cancer risk, two cohort studies have observed null associations. Dietary cholesterol and eggs have been positively associated with ovarian cancer risk. A pooled analysis was conducted on 12 cohort studies. Among 523,217 women, 2,132 incident epithelial ovarian cancer cases were identified. Study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Total fat intake was not associated with ovarian cancer risk (pooled multivariate RR = 1.08, 95% CI 0.86-1.34 comparing > or =45 to 30 |
| Databáze: | OpenAIRE |
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