Increased proliferation of eosinophil clusters in myelodysplastic syndromes
| Autor: | Shigeru Tomoyasu, Akihiro Yokoyama, Taijiro Ishiyama, Keiichirou Kawakami, M. Koike, Takeshi Nakamaki, Nobuyoshi Tsuruoka |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cancer Research
medicine.medical_treatment CFU-GM Biology Colony-Forming Units Assay Bone Marrow hemic and lymphatic diseases Eosinophilia Granulocyte Colony-Stimulating Factor medicine Humans Aged Growth factor Myelodysplastic syndromes Anemia Refractory Granulocyte-Macrophage Colony-Stimulating Factor Hematology respiratory system Eosinophil Hematopoietic Stem Cells medicine.disease Recombinant Proteins Eosinophils Granulocyte macrophage colony-stimulating factor Cytokine medicine.anatomical_structure Oncology Myelodysplastic Syndromes Toxicity Immunology Female Interleukin-3 Interleukin-5 medicine.symptom Cell Division medicine.drug |
| Zdroj: | Leukemia Research. 19:915-920 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/0145-2126(95)00083-6 |
| Popis: | A patient with myelodysplastic syndromes (MDS) developed eosinophilia during treatment with recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF). To study the mechanism of this eosinophilia, we investigated the proliferation of eosinophil colony-forming units (CFU-Eo) in nine patients and four healthy controls. Eosinophil clusters increased significantly in the patients (P < 0.01) compared with controls, but eosinophil colonies were not different between controls and MDS patients. In addition, the eosinophil clusters were significantly increased with rhGM-CSF in MDS patients compared with controls, although serum GM-CSF concentrations were similar in both groups. These results suggest that eosinophil clusters are increased in MDS either through abnormal progenitor proliferation or hypersensitivity to GM-CSF. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect