A Glycyrrhetinic Acid-Modified Curcumin Supramolecular Hydrogel for liver tumor targeting therapy
| Autor: | Yanbin Cai, Jie Zhan, Mingcai Song, Jie Gao, Guoqin Chen, Zhimou Yang, Yang Shi, Jinliang Li |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Curcumin
02 engineering and technology 010402 general chemistry 01 natural sciences Article chemistry.chemical_compound Drug Delivery Systems Neoplasms Fluorescence microscope Humans MTT assay Cytotoxicity Multidisciplinary Hydrogels Hep G2 Cells Glutathione 021001 nanoscience & nanotechnology In vitro 0104 chemical sciences Bioavailability chemistry Biochemistry Self-healing hydrogels Glycyrrhetinic Acid 0210 nano-technology |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep44210 |
| Popis: | Curcumin (Cur), a phenolic anti-oxidant compound obtained from Curcuma longa plant, possesses a variety of therapeutic properties. However, it is suffered from its low water solubility and low bioavailability property, which seriously restricts its clinical application. In this study, we developed a glycyrrhetinic acid (GA) modified curcumin supramolecular pro-gelator (GA-Cur) and a control compound Nap-Cur by replacing GA with the naphthylacetic acid (Nap). Both compounds showed good water solubility and could form supramolecular gels by disulfide bond reduction triggered by glutathione (GSH) in vitro. Both formed gels could sustainedly release Cur in buffer solutions. We also investigated the cytotoxicity of pro-gelators to HepG2 cells by a MTT assay and determined the cellular uptake behaviours of them by fluorescence microscopy and LC-MS. Due to the over expression of GA receptor in liver cancer cells, our pro-gelator of GA-Cur showed an enhanced cellular uptake and better inhibition capacity to liver tumor cells than Nap-Cur. Therefore, the GA-Cur could significantly inhibit HepG2 cell growth. Our study provides a novel nanomaterial for liver tumor chemotherapy. |
| Databáze: | OpenAIRE |
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