Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats
| Autor: | Beatrice Guardiola-Lemaitre, Susan L.F. Chan, Agnès Pelé-Tounian, Dominique Manechez, Frédéric Rondu, Noel G. Morgan, Azzdine Lamouri, Estera Touboul, Alain Ktorza, Marie-Hélène Giroix, Luc Pénicaud, Jean-Jacques Godfroid, Bruno Pfeiffer, Pierre Renard, Gaëlle Le Bihan |
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| Přispěvatelé: | Institut de Recherches Servier, SERVIER, Les Laboratoires SERVIER, Institut de Recherche Servier, Institut de Recherches Internationales Servier (IRIS-Servier), Centre National de la Recherche Scientifique (CNRS), Neurobiologie, plasticité tissulaire et métabolisme énergétique (NPTME), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physiopathologie de la nutrition (LPN), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7) |
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Imidazoline receptor In Vitro Techniques Carbohydrate metabolism Biology Piperazines Diabetes Mellitus Experimental Islets of Langerhans 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Diabetes mellitus Internal medicine Insulin Secretion medicine Diazoxide Animals Hypoglycemic Agents Insulin Rats Wistar Antihypertensive Agents Pancreatic hormone ComputingMilieux_MISCELLANEOUS 030304 developmental biology Pharmacology 0303 health sciences Imidazoles medicine.disease Rats Rats Zucker Glucose Endocrinology Liver L-Glucose chemistry Basal (medicine) Glucose Clamp Technique Rubidium Radioisotopes [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Journal of Pharmacology European Journal of Pharmacology, Elsevier, 1999, 377 (1), pp.81-7 |
| ISSN: | 0014-2999 |
| Popis: | We have investigated the possible mechanisms underlying the antihyperglycaemic effect of the imidazoline derivative S-22068. In vitro, in the presence of 5 mmol/l glucose, S-22068 (100 micromol/l) induced a significant and sustained increase in insulin secretion from isolated, perifused, rat islets and a marked sensitization to a subsequent glucose challenge (10 mmol/l). S-22068 (100 micromol/l was able to antagonize the stimulatory effect of diazoxide on 86Rb efflux from preloaded islets incubated in the presence of 20 mmol/l glucose. Experiments were also performed to investigate whether S-22068 can alter glucose turnover and peripheral insulin sensitivity in vivo in mildly diabetic rats and obese, insulin resistant, Zucker rats. Neither glucose production nor individual tissue glucose utilization was modified by S-22068 in either group of rats. Similar results were obtained whether the studies were performed under basal conditions or during euglycaemic/hyperinsulinemic clamps. The results suggest that S-22068 exerts part of its antihyperglycaemic effect by promoting insulin secretion without alteration of peripheral insulin sensitivity. |
| Databáze: | OpenAIRE |
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