Predictive monitoring and therapeutic immune biomarkers in the management of clinical complications of COVID-19

Autor:	Amir Roudgari, Mehrnoosh Doroudchi, Golnar Sabetian, Shahram Paydar, Najmeh Rokhtabnak, Hamed Fouladseresht, Hossein Abdolrahimzadehfard
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	ssRNA single-stranded RNA CT computerized tomography Complications Endocrinology Diabetes and Metabolism RA rheumatoid arthritis Ab antibody LY6E lymphocyte antigen 6 family member E AT1R Ang II receptor type 1 MDA-5 melanoma differentiation-associated protein-5 Immunopathology GzmB granzyme B SAA serum amyloid A SARS severe acute respiratory Medicine DIC disseminated intravascular coagulation ORF-1ab open reading frame 1ab RT-qPCR real-time PCR-quantitative PCR Fio2 fraction of inspired oxygen Lung COVID-19 coronavirus disease-2019 LDH lactate dehydrogenase AICD activation-induced cell death IRF-1 IFN regulatory factor 1 C3 and C5 complement proteins RBD receptor-binding domain IP-10 interferon (IFN-γ inducible protein-10 CXCR chemokine (C-X-C motifligand receptor Acquired immune system Prognosis KL-6 Krebs von den Lungen-6 JUN c-Jun N-terminal kinases NSP non-structural proteins Cytokines BEC bronchial epithelial cell rhIL-1ra recombinant human IL-1 receptor Antibody Cytokine Release Syndrome GM-CSF granulocyte-macrophage colony-stimulating factor NK natural killer WBC white blood cell MOF multiple organ failure CP convalescent plasma PLR platelet-to-lymphocyte ratios FcγR Fc gamma receptor Immunology HLH hemophagocytic lymphohistiocytosis General Biochemistry Genetics and Molecular Biology Article PKR protein kinase R MERS middle east respiratory syndrome nAb neutralizing antibody LWR lymphocyte-to-WBCs ratio PT prothrombin time IVIg intravenous immunoglobulin Humans mAb monoclonal antibody APTT activated partial thromboplastin time NFkB nuclear factor kappa-light-chain-enhancer of activated B cells ARDS acute respiratory distress syndrome Monitoring Physiologic ESR erythrocyte sedimentation rate rIL7 recombinant IL-7 Pao2 partial pressure of oxygen rBP-C33 Leurecombinant surfactant protein C analogue HLA human leukocyte antigen MUC mucin scFv single-chain variable fragment Biomarker medicine.disease CTL cytotoxic T lymphocyte Immunity Innate IL interleukin RAS regulator of the renin-angiotensin system Clinical trial TNF-α tumor necrosis factor APC antigen-presenting cell siRNA small interfering RNA CXCL chemokine (C-X-C motifligand PRR pattern recognition receptors NLRP3 nod-like receptor protein 3 TMPRSS2 transmembrane serine protease 2 S-protein spike-protein Biomarkers ACEI ACE inhibitor LAG-3 lymphocyte-activation gene 3 MIP macrophage inflammatory proteins Chemokine NCT clinicaltrials.gov identifier CCL chemokine (C-C motifligand TLR toll like receptor CQ chloroquine NKRF NFkB repressing factor Cytokine storm C-GAS-STING cGAMP binds to stimulator of interferon genes rhACE2-Fc fusion proteins recombinant human ACE2-Fc fusion proteins srhACE2 soluble recombinant human (srhACE2 CRP c-reactive protein BALF bronchoalveolar lavage fluid Immunology and Allergy TGF transforming growth factor Respiratory Distress Syndrome BTK Bruton tyrosine kinase biology ICU admissions to intensive care units IFITM interferon-induced transmembrane protein PD1 programmed cell death protein 1 CRS cytokine release syndrome VEGF vascular endothelial growth factor ISG induction of IFN-stimulated gene PCT procalcitonin S1PR sphingosine-1-phosphate receptors RIG retinoic acid-inducible gene-I CCR chemokine (C-C motifligand receptor TIM-3 T-cell immunoglobulin mucin 3 Ang angiotensin Biomarker (medicine) AAK-1 activated protein (AP2 associated kinase 1 Chemokines AEC alveolar epithelial cells ACE angiotensin-converting enzyme SP surfactant NLR neutrophil-to-lymphocyte ratio SARS-CoV severe acute respiratory syndrome coronavirus ChiCTR chinese clinical trial registry JAK janus kinase Th helper T cell Immune system IFN interferon NTD N terminal domain ComputingMethodologies_COMPUTERGRAPHICS HR-2 heptad repeat region-2 business.industry SARS-CoV-2 COVID-19 HCQ hydroxychloroquine SPo2 arterial oxygen saturation MCP monocyte chemoattractant protein Treg regulatory T cells RLR RIG-I-like receptors biology.protein ARB Ang II receptor blocker dsRNA double-stranded RNA business GAK G-associated kinase N nucleocapsid
Zdroj:	Cytokine & Growth Factor Reviews
ISSN:	1879-0305 1359-6101
Popis:	Graphical abstract The coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), appears with a wide spectrum of mild-to-critical clinical complications. Many clinical and experimental findings suggest the role of inflammatory mechanisms in the immunopathology of COVID-19. Hence, cellular and molecular mediators of the immune system can be potential targets for predicting, monitoring, and treating the progressive complications of COVID-19. In this review, we assess the latest cellular and molecular data on the immunopathology of COVID-19 according to the pathological evidence (e.g., mucus and surfactants), dysregulations of pro- and anti-inflammatory mediators (e.g., cytokines and chemokines), and impairments of innate and acquired immune system functions (e.g., mononuclear cells, neutrophils and antibodies). Furthermore, we determine the significance of immune biomarkers for predicting, monitoring, and treating the progressive complications of COVID-19. We also discuss the clinical importance of recent immune biomarkers in COVID-19, and at the end of each section, recent clinical trials in immune biomarkers for COVID-19 are mentioned.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e0fbf581bda9815dda8e7df930533e http://europepmc.org/articles/PMC7544568 Zobrazit plný text záznamu Full Text from ScienceDirect