Clinical and Serological Evaluation of LINDA Virus Infections in Post-Weaning Piglets

Autor: Sandra Högler, Lukas Schwarz, Kerstin Seitz, Till Rümenapf, Christiane Riedel, Herbert Weissenböck, Katharina Buczolich, Andrea Klang, Hann-Wei Chen, Elena L. Sassu, Benjamin Lamp, Sophie Dürlinger, Marlene Mötz, Alexandra Kiesler, Andrea Ladinig, Peter D. Kirkland, Helga Petznek
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Viruses
Volume 11
Issue 11
Viruses, Vol 11, Iss 11, p 975 (2019)
ISSN: 1999-4915
DOI: 10.3390/v11110975
Popis: The novel pestivirus species known as lateral-shaking inducing neuro-degenerative agent (LINDA) virus emerged in 2015 in a piglet-producing farm in Austria. Affected piglets showed strong congenital tremor as a result of severe lesions in the central nervous system. Here, we report the results of a controlled animal infection experiment. Post-weaning piglets were infected with LINDA to determine the susceptibility of pigs, the clinical consequences of infection and the humoral immune response against LINDA. No clinically overt disease signs were observed in the piglets. Viremia was hardly detectable, but LINDA was present in the spleen and several lymphatic organs until the end of the experiment on day 28 post-infection. Oronasal virus shedding together with the infection of one sentinel animal provided additional evidence for the successful replication and spread of LINDA in the piglets. Starting on day 14 post-infection, all infected animals showed a strong humoral immune response with high titers of neutralizing antibodies against LINDA. No cross-neutralizing activity of these sera with other pestiviral species was observed. According to these data, following postnatal infection, LINDA is a rather benign virus that can be controlled by the pig&rsquo
s immune system. However, further studies are needed to investigate the effects of LINDA on the fetus after intrauterine infection.
Databáze: OpenAIRE
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