From the Heart to the Lung: A Case of Drug Toxicity
| Autor: | Maria Teresa Vilaça, Carina Rôlo Silvestre, Ricardo José Cordeiro, André Nunes, Teresa Falcão, António Domingos, João Eusébio |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Lung Diseases
Drug medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions Pulmonary toxicity media_common.quotation_subject Amiodarone Gastroenterology Drug withdrawal Internal medicine medicine Humans Lung Aged media_common business.industry Articles General Medicine medicine.disease Diagnosis of exclusion Discontinuation medicine.anatomical_structure Toxicity Female Lung Diseases Interstitial business Anti-Arrhythmia Agents medicine.drug |
| Zdroj: | The American Journal of Case Reports |
| ISSN: | 1941-5923 |
| DOI: | 10.12659/ajcr.929906 |
| Popis: | Patient: Female, 71-year-old Final Diagnosis: Drug toxicity Symptoms: Dry cough • dyspnea Medication: — Clinical Procedure: Drug withdrawal Specialty: Pulmonology Objective: Unusual clinical course Background: Amiodarone is an anti-arrthymic drug used to treat and prevent several types of dysrhythmias. This drug is known for multiple-organ toxicity. Lung toxicity occurs in about 1% to 5% of cases. A wide variety of lung manifestations have been described, from mild to severe forms. Pulmonary toxicity can be acute, sub-acute, or chronic. Amiodarone-induced lung toxicity is a diagnosis of exclusion. The main treatment is discontinuation of the drug. Lung disease may progress initially due to the prolonged half-life and the accumulation of amiodarone in adipose tissue. Regarding the prognosis, lung toxicity can be reversible, but in some cases, it is irreversible and is sometimes fatal. The risks associated with its use must always be considered. Amiodarone should only be used for short periods. Case Report: The authors present a case of a 71-year-old female patient, taking amiodarone 200 mg/day for 18 months. The patient presented with amiodarone-induced lung toxicity. After drug withdrawal, without corticosteroid therapy, we observed clinical, functional, and radiological improvement. Conclusions: This case shows that not all cases of amiodarone-induced lung toxicity require corticosteroid therapy, and highlights that is important to consider this diagnosis in patients on amiodarone therapy with respiratory symptoms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|