Uterine prostaglandin levels following stimulation of the decidual cell reaction: effects of indomethacin and tranylcypromine
| Autor: | Barry E. Ledford, Haldor T. Jonsson, Judith C. Rankin, Billy Baggett |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Indomethacin Uterus Prostaglandin Prostacyclin Stimulation Biochemistry chemistry.chemical_compound Mice Endocrinology Pregnancy Internal medicine medicine Cyclic AMP Decidua Animals Decidual cells Castration Progesterone Estradiol Prostaglandins E Tranylcypromine Prostaglandins F Organ Size eye diseases medicine.anatomical_structure chemistry lipids (amino acids peptides and proteins) Female sense organs Sesame Oil medicine.drug Prostaglandin E |
| Zdroj: | Prostaglandins. 18(6) |
| ISSN: | 0090-6980 |
| Popis: | Prostaglandin E (PGE) and F (PGF) levels were measured in mouse uteri at various times after either trauma (hemostat crusing) or oil stimulation of the decidual cell reaction (DCR). The oil induced DCR led to an early increase (within 5 min) in both PGE and PGF levels. Both returned to baseline by 1 h after stimulation. A second peak in PGF levels was observed at 120 min after oil stimulation. This study demonstrates a distinct difference between the pattern of PGE and PGF changes in the uterus following oil stimulation of the DCR. Indomethacin pretreatment completely blocked the oil stimulated DCR as well as all prostaglandin increases following either stimulus. The trauma stimulated DCR was not completely blocked by indomethacin pretreatment. Pretreatment with tranylcypromine, an inhibitor of prostacyclin biosynthesis, did not block the prostaglandin E and F increases, but did block the oil stimulated DCR. These findings suggest that prostacyclin may be an early mediator of the DCR. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|