Coronary Artery Disease in Diabetic Patients With Nephropathy
| Autor: | Connie L. Manske |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Coronary Disease Vascular permeability Nephropathy Diabetic nephropathy Coronary artery disease chemistry.chemical_compound Risk Factors Diabetes mellitus Internal medicine Internal Medicine medicine Humans Diabetic Nephropathies Proteinuria business.industry Cholesterol nutritional and metabolic diseases medicine.disease Diabetes Mellitus Type 1 chemistry Cardiology lipids (amino acids peptides and proteins) medicine.symptom business Lipoprotein |
| Zdroj: | American Journal of Hypertension. 6:367S-374S |
| ISSN: | 1941-7225 0895-7061 |
| DOI: | 10.1093/ajh/6.11.367s |
| Popis: | Patients with juvenile-onset, insulin-dependent diabetes mellitus (IDDM) are at high risk of premature coronary artery disease. The risk is concentrated in diabetic patients who develop nephropathy. Synergy in atherogenesis is likely to be present between hyperglycemia and the metabolic alterations of diabetic nephropathy, which include hypertension, hypercholesterolemia, and high lipoprotein (a) levels. The accumulation of advanced glycation end-products in blood vessel walls and on lipoproteins may result in increased vascular permeability and uptake of cholesterol, particularly in the setting of hypertension and hypercholesterolemia. The net result may be acceleration of atherogenesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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