Pharmacokinetics of chromium-enriched yeast in rats following oral administration

Autor: Shuang-Qing, Zhang, Xian-Wu, Qin, Yan, Zhang
Rok vydání: 2022
Předmět:
Zdroj: Naunyn-Schmiedeberg's Archives of Pharmacology. 396:167-170
ISSN: 1432-1912
0028-1298
DOI: 10.1007/s00210-022-02334-z
Popis: Chromium (Cr) is required for carbohydrate, lipid, and protein metabolisms in humans and animals. Cr insufficiency is associated with diabetes and cardiovascular disease. Chromium-enriched yeast (CrY) is a widely used Cr dietary supplement, but its pharmacokinetics remains unavailable. CrY was orally administered to rats at a single dose of 1 mg Cr/kg, and plasma Cr concentration at different time points was measured by inductively coupled plasma mass spectrometry. Pharmacokinetics of CrY in rats was well fitted to a non-compartmental model. Plasma Cr concentration reached the maximum of 8.68 ± 2.87 ng/mL at 0.25 h, and gradually decreased to 4.05 ± 0.47 ng/mL at 24 h. CrY was rapidly absorbed into the blood and was slowly eliminated after the oral administration, which could lead to the accumulation of Cr in vivo.
Databáze: OpenAIRE
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