Cancer Risk in the Heart Failure Population: Epidemiology, Mechanisms, and Clinical Implications
| Autor: | Francesco Elia, Carlo G. Tocchetti, Eliana De Rosa, Alessandra Cuomo, Valentina Mercurio, Flora Pirozzi, Michele Russo, Pietro Ameri, Alessandra Ghigo, Umberto Attanasio, Riccardo Franco |
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| Přispěvatelé: | Cuomo, A., Pirozzi, F., Attanasio, U., Franco, R., Elia, F., De Rosa, E., Russo, M., Ghigo, A., Ameri, P., Tocchetti, C. G., Mercurio, V. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Aging Population Antineoplastic Agents Heart failure 030204 cardiovascular system & hematology medicine.disease_cause Pathophysiology 03 medical and health sciences 0302 clinical medicine Internal medicine Neoplasms Epidemiology medicine Humans education Cancer Cardiotoxicity education.field_of_study Cardio-oncology (EH Yang Section Editor) Cardio-oncology Risk factors business.industry Incidence (epidemiology) Incidence medicine.disease 030220 oncology & carcinogenesis Cancer risk business Carcinogenesis |
| Zdroj: | Current Oncology Reports |
| Popis: | Purpose of Review Along with population aging, the incidence of both heart failure (HF) and cancer is increasing. However, little is known about new-onset cancer in HF patients. This review aims at showing recent discoveries concerning this subset of patients. Recent Findings Not only cancer and HF share similar risk factors but also HF itself can stimulate cancer development. Some cytokines produced by the failing heart induce mild inflammation promoting carcinogenesis, as it has been recently suggested by an experimental model of HF in mice. Summary The incidence of new-onset cancer is higher in HF patients compared to the general population, and it significantly worsens their prognosis. Moreover, the management of HF patients developing new-onset cancer is challenging, especially due to the limited therapeutic options for patients affected by both cancer and HF and the higher risk of cardiotoxicity from anticancer drugs. |
| Databáze: | OpenAIRE |
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