Is there a relationship between clozapine and obsessive-compulsive disorder?: A retrospective chart review
| Autor: | Jonathan O. Cole, Anand P. Popli, S. Nassir Ghaemi, Carlos A. Zarate, Srinivasan S. Pillay |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Obsessive-Compulsive Disorder Psychosis medicine.medical_specialty Pediatrics lcsh:RC435-571 MEDLINE Drug Administration Schedule Patient Admission lcsh:Psychiatry mental disorders medicine Humans Psychiatry Clozapine Retrospective Studies Dose-Response Relationship Drug Incidence (epidemiology) Retrospective cohort study Middle Aged medicine.disease humanities Natural history Psychiatry and Mental health Clinical Psychology Psychotic Disorders Schizophrenia Female Schizophrenic Psychology Psychology Anxiety disorder medicine.drug |
| Zdroj: | Comprehensive Psychiatry, Vol 36, Iss 4, Pp 267-270 (1995) |
| Popis: | The emergence of obsessive-compulsive symptoms during clozapine treatment has been reported in recent case studies, yet the incidence and significance of this finding is still unclear pending reliable data from a larger sample of patients. Hospital records of 142 randomly selected inpatients started on clozapine treatment at McLean Hospital before July 1, 1992, were reviewed retrospectively. Based on a limited retrospective chart review, there were no definitive cases of patients who developed obsessive-compulsive disorder (OCD) or whose OCD worsened as a result of clozapine treatment. Although some fluctuation of OCD symptoms may have occurred in two cases, it is unclear whether those symptoms were related to treatment with clozapine (or other psychotropic drugs) or to undulations in the natural history of OCD. No definitive relationship between OCD symptoms and clozapine treatment could be established in this limited study. Further clarification of this matter awaits outcome research using prospective methodologies. |
| Databáze: | OpenAIRE |
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