Recovery of foot drop in chronic inflammatory demyelinating polyneuropathy (CIDP)
| Autor: | Dinushi Weerasinghe, Aravindhan Veerapandiyan, David N. Herrmann, Eric L. Logigian, Michael Stanton, Chary Akmyradov |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Foot drop Adolescent Physiology Disease duration Chronic inflammatory demyelinating polyneuropathy 030105 genetics & heredity 03 medical and health sciences Cellular and Molecular Neuroscience Young Adult 0302 clinical medicine Physiology (medical) Internal medicine Medicine Humans Child Peroneal Neuropathies Aged Retrospective Studies Aged 80 and over business.industry Electrodiagnosis Recovery of Function Middle Aged medicine.disease Compound muscle action potential Axon loss Polyradiculoneuropathy Chronic Inflammatory Demyelinating Cardiology Female Neurology (clinical) Presentation (obstetrics) medicine.symptom business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | MusclenerveREFERENCES. 64(1) |
| ISSN: | 1097-4598 |
| Popis: | Foot drop is common in chronic inflammatory demyelinating polyneuropathy (CIDP), but its prognosis is uncertain.CIDP patients with less than anti-gravity strength (3/5 power) of ankle dorsiflexion (ADF) on Medical Research Council manual muscle testing on presentation at our center were identified by retrospective review. After initiation of standard treatment, ADF power was serially tabulated, and predictors of recovery were determined.Of the 27 identified patients, ADF power at presentation was3/5 in 48/54 legs. At 1 y after treatment, ADF power improved to/= 3/5 in 17/27 patients in one (N = 6) or both (N = 11) legs. On multi-variate analysis, predictors of recovery of ADF power were tibialis anterior compound muscle action potential amplitude at presentation, shorter disease duration, and female gender.Foot drop improves to anti-gravity power in most treated CIDP patients depending in part on the severity of fibular motor axon loss at onset of treatment. |
| Databáze: | OpenAIRE |
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