Synthesis and evaluation of technetium-99m monocationic mixed ligand complexes of phenyl substituted/condensed tetradentate Schiff's bases and trimethylphosphine
| Autor: | Anca Constantinescu, James R. Corbett, N. C. Goomer, Robert W. Parkey, Padmakar V. Kulkarni, P.P. Antich |
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| Rok vydání: | 1992 |
| Předmět: |
Biodistribution
Cyclodextrins Schiff base Stereochemistry Phosphines Acetylacetone Trimethylphosphine Imine beta-Cyclodextrins Rats Inbred Strains General Medicine Organotechnetium Compounds Medicinal chemistry Chemical synthesis 2-Hydroxypropyl-beta-cyclodextrin Rats Solutions chemistry.chemical_compound chemistry Salicylaldehyde Phenyl group Animals Tissue Distribution Schiff Bases |
| Zdroj: | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 19(6) |
| ISSN: | 0883-2897 |
| Popis: | Tc-99m monocationic mixed ligand complexes of phenyl substituted/condensed Schiff's bases, N,N′-ethylene-bis-(benzoylacetone imine) (Lb) or N,N′-ethylene-bis-(salicylaldehyde imine) (Lc) or N,N′-ethylene-bis-(2-hydroxyacetophenone imine) (Ld) and trimethylphosphine were synthesized to determine the influence of the presence of a phenyl group in these tracers on their heart uptake in rats. A new formulation procedure using aq. β-hydroxypropylcyclodextrin (HPB) solution was developed for intravenous administration of nonpolar 99mTc complexes. Comparison of biodistribution data for the reference 99mTc complex from N,N′-ethylene-bis-(acetylacetone imine) and trimethylphosphine using HPB formulation and alternate formulation (0.9% saline) showed the same results. Biodistribution of the title 99mTc complexes, [99mTc Lb (PMe3)2]+, [99mTc Lc (PMe3)2]+ and [99mTc Ld (PMe3)2]+ showed heart-to-blood activity ratios of 1.7, 2.1 and 1.7, respectively, at 15 min post-injection in rats. |
| Databáze: | OpenAIRE |
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