Maternal association and influence of DHFR 19 bp deletion variant predisposes foetus to anencephaly susceptibility: a family-based triad study
| Autor: | Kattekola Rebekah Prasoona, B Srinadh, T Muni Kumari, T. Sunitha, Akka Jyothy |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Genotype Health Toxicology and Mutagenesis Clinical Biochemistry 030105 genetics & heredity Biology Reductase Biochemistry Fetal Development 03 medical and health sciences Risk Factors Anencephaly medicine Humans heterocyclic compounds Family Genetic Predisposition to Disease Sequence Deletion Genetics chemistry.chemical_classification Fetus Triad (anatomy) medicine.disease Tetrahydrofolate Dehydrogenase 030104 developmental biology medicine.anatomical_structure Enzyme chemistry Female Maternal Inheritance Family based |
| Zdroj: | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 23(7) |
| ISSN: | 1366-5804 |
| Popis: | Previous studies have not used family-based methods to evaluate maternal-paternal genetic effects of the folate metabolizing enzyme, dihydro folate reductase (DHFR) essential during embryogenesis. Present study focuses on evaluating the association and influence of parental genetic effects of DHFR 19 bp deletion in the development of foetal neural tube defects (NTDs) using family-based triad approach.The study population (n = 924) including 124 NTD case-parent trios (n = 124 × 3 = 372) and 184 healthy control-parent trios (n = 184 × 3 = 552) from Telangana, India, was genotyped for DHFR 19 bp deletion. Statistical analysis was used by SPSS and parent-of-origin effects (POE).Foetuses with deletion genotype (DD) were at risk of developing anencephaly (OR = 3.26, p = 0.020). Among parents, increased maternal risk of having an anencephaly foetus (OR = 2.66, p = 0.028) was observed in mothers with DD genotype. In addition, POE analysis also demonstrated higher risk of maternal transmission of the deletion allele to anencephaly foetus compared with paternal transmission (OR = 6.00, p = 0.016). Interestingly, maternal-paternal-offspring genotype incompatibility revealed maternal deletion genotype (DD) in association with paternal heterozygous deletion genotype (WD) significantly increased risk for NTDs (OR = 5.29, p = 0.013).This study, using family-based case-parent and control-parent triad approach, is the first to report influence of maternal transmission of DHFR 19 bp deletion in the development of anencephaly in the foetus. |
| Databáze: | OpenAIRE |
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