HUMAN PAPILLOMAVIRUS AND ABNORMAL CERVICAL LESIONS AMONG HIV-INFECTED WOMEN IN HIV-DISCORDANT COUPLES FROM KENYA
| Autor: | James Kiarie, Anne F. Rositch, Rose Bosire, Jennifer S. Smith, Carey Farquhar, Joy Alison Cooper, Brandon L. Guthrie, Robert Y. Choi |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Population Human immunodeficiency virus (HIV) Uterine Cervical Neoplasms HIV Infections Dermatology medicine.disease_cause Article 03 medical and health sciences Young Adult 0302 clinical medicine Cytology Genotype Atypical Squamous Cells of the Cervix Prevalence Medicine Humans 030212 general & internal medicine Prospective Studies Human papillomavirus Prospective cohort study education education.field_of_study 030505 public health business.industry Obstetrics Papillomavirus Infections HPV infection virus diseases Cervical cytology Middle Aged medicine.disease Kenya female genital diseases and pregnancy complications Infectious Diseases Cross-Sectional Studies Sexual Partners Carcinoma Squamous Cell Female Squamous Intraepithelial Lesions of the Cervix 0305 other medical science business |
| Zdroj: | Sex Transm Infect |
| Popis: | ObjectiveHIV infection increases the risk of high-grade cervical neoplasia and invasive cervical carcinoma. The study addresses the limited data describing human papillomavirus (HPV) infection and cervical neoplasia among HIV-infected women in HIV-discordant relationships in sub-Saharan Africa, which is needed to inform screening strategies.MethodsA cross-sectional study of HIV-infected women with HIV-uninfected partners was conducted to determine the distribution of type-specific HPV infection and cervical cytology. This study was nested in a prospective cohort recruited between September 2007 and December 2009 in Nairobi, Kenya. Cervical cells for HPV DNA testing and conventional cervical cytology were collected. HPV types were detected and genotyped by Roche Linear Array PCR assay.ResultsAmong 283 women, the overall HPV prevalence was 62%, and 132 (47%) had ≥1 high-risk (HR)-HPV genotype. Of 268 women with cervical cytology results, 18 (7%) had high-grade cervical lesions or more severe by cytology, of whom 16 (89%) were HR-HPV-positive compared with 82 (41%) of 199 women with normal cytology (pConclusionHR-HPV prevalence was high in this population of HIV-infected women with an uninfected partner. Choice of screening for all HR genotypes versus a subset of HR genotypes in these HIV-infected women will strongly affect the performance of an HPV screening strategy relative to cytological screening. Regional and subpopulation differences in HR-HPV genotype distributions could affect screening test performance. |
| Databáze: | OpenAIRE |
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