SDF-1/CXCL12 and CXCR4 gene variants, and elevated serum SDF-1 levels are associated with preeclampsia
| Autor: | Özlem Bozoklu Akkar, Savas Karakus, Ali Cetin, Enver Sancakdar, Caglar Yildiz, Binnur Bagci, Gokhan Bagci |
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| Přispěvatelé: | [Karakus, Savas -- Yildiz, Caglar -- Akkar, Ozlem -- Cetin, Ali] Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Sch Hlth Sci, Dept Nutr & Dietet, Sivas, Turkey -- [Bagci, Gokhan] Cumhuriyet Univ, Sch Med, Dept Med Genet, Sivas, Turkey -- [Sancakdar, Enver] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey |
| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Receptors CXCR4 CXCL12 gene Single-nucleotide polymorphism Polymorphism Single Nucleotide CXCR4 SDF-1 polymorphism Preeclampsia preeclampsia Andrology Young Adult 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy Polymorphism (computer science) Genotype Internal Medicine Humans Medicine SNP Allele frequency Genotyping 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology medicine.disease Molecular biology Chemokine CXCL12 030104 developmental biology Case-Control Studies Female CXCR4 gene business Biomarkers |
| Zdroj: | Hypertension in Pregnancy. 36:124-130 |
| ISSN: | 1525-6065 1064-1955 |
| DOI: | 10.1080/10641955.2016.1250904 |
| Popis: | WOS: 000403435800002 PubMed ID: 28001450 Objective: We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE).Methods: In total, 89 women with PE and 89 control women were included in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism method. Enzyme-linked immunosorbent assay method was used to measure serum SDF-1 level.Results: For SDF-1 3A SNP, the frequency of GA genotype, total number of GA and AA genotypes, and the A allele frequency was higher in PE patients than controls (p = 0.04, 0.023, and 0.029, respectively). For CXCR4 SNP, the frequency of CT genotype, total number of CT and TT genotypes, and the T allele frequency were higher in PE patients than controls (p = 0.04, 0.006, and 0.005, respectively). SDF-1 serum level was detected higher in preeclamptic women compared with controls (p = 0.001). In PE patients, there was no significant association between serum SDF-1 levels and genotypes of SDF-1 3A SNP. SDF-1 level was significantly higher in patients bearing CXCR4 CT genotype than CC genotype (p = 0.001). Furthermore, SDF-1 levels in patients bearing CT+TT genotype were found higher than that of patients with CC genotypes (p = 0.001).Conclusion: Results of our study suggest that SDF-1 3A and CXCR4 polymorphisms and elevated serum SDF-1 levels may have a role in the development of PE. |
| Databáze: | OpenAIRE |
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