Expression of thymidylate synthase (TS) and its prognostic significance in patients with cutaneous angiosarcoma
| Autor: | Y. Okubo, D. Utsumi, Masahito Yasuda, A. Bolag, Osamu Ishikawa, Kengo Takahashi, Akira Shimizu, Kyoichi Kaira |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Prognostic variable Skin Neoplasms Multivariate analysis Hemangiosarcoma 030230 surgery Thymidylate synthase 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Angiosarcoma Progression-free survival Stage (cooking) Univariate analysis biology business.industry Thymidylate Synthase Prognosis Immunohistochemistry Progression-Free Survival Survival Rate 030220 oncology & carcinogenesis biology.protein business |
| Zdroj: | Neoplasma. 64:916-921 |
| ISSN: | 1338-4317 |
| DOI: | 10.4149/neo_2017_615 |
| Popis: | Cutaneous angiosarcoma (CA) is extremely rare, and little is known about the biological significance of possible biomarkers for chemotherapeutic agents. Thymidylate synthase (TS) is an attractive target for cancer treatment in various human neoplasms. It remains unclear whether the expression of TS is associated with the clinicopathological features of CA patients. The aim of this study was to elucidate the relationship between TS expression and the clinicopathological significance in CA patients. Fifty-one patients with CA were included in this study. TS expression and Ki-67 labeling index were examined using immunohistochemical analysis. TS was positively expressed in 39% (20/51) of CA patients. No statistically significant prognostic factor was identified as a predictor of overall survival (OS) for all patients by univariate analysis, whereas a significant prognostic variable for progression free survival (PFS) was found to be the clinical stage. In addition, both univariate and multivariate analyses confirmed that positive expression of TS was a significant predictor of worse PFS in CA patients of clinical stage 1. CONCLUSION Positive TS expression in CA was identified as a significant predictor of worse outcome in patients of clinical stage 1. |
| Databáze: | OpenAIRE |
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