Predictors of 18F-DCFPyL PET/CT Positivity in Patients with Biochemical Recurrence of Prostate Cancer After Local Therapy

Autor: Mena, Esther, Rowe, Steven P., Shih, Joanna H., Lindenberg, Liza, Turkbey, Baris, Fourquet, Aloyse, Lin, Frank I., Adler, Stephen, Eclarinal, Philip, McKinney, Yolanda L., Citrin, Deborah E., Dahut, William, Wood, Bradford J., Chang, Richard, Levy, Elliot, Merino, Maria, Gorin, Michael A., Pomper, Martin G., Pinto, Peter A., Eary, Janet F., Choyke, Peter L., Pienta, Kenneth J.
Rok vydání: 2021
Předmět:
Zdroj: J Nucl Med
ISSN: 2159-662X
0161-5505
DOI: 10.2967/jnumed.121.262347
Popis: Our objective was to investigate the factors predicting scan positivity and disease location in patients with biochemical recurrence (BCR) of prostate cancer (PCa) after primary local therapy using prostate-specific membrane antigen–targeted (18)F-DCFPyL PET/CT. Methods: This was a 2-institution study including 245 BCR PCa patients after primary local therapy and negative results on conventional imaging. The patients underwent (18)F-DCFPyL PET/CT. We tested for correlations of lesion detection rate and disease location with tumor characteristics, time from initial therapy, prostate-specific antigen (PSA) level, and PSA doubling time (PSAdt). Multivariate logistic regression analyses were used to determine predictors of a positive scan. Regression-based coefficients were used to develop nomograms predicting scan positivity and extrapelvic disease. Results: Overall, 79.2% (194/245) of patients had a positive (18)F-DCFPyL PET/CT result, with detection rates of 48.2% (27/56), 74.3% (26/35), 84% (37/44), 96.7% (59/61), and 91.8% (45/49) for PSAs of
Databáze: OpenAIRE
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