| Autor: |
Joseph Lehár, Giordano Caponigro, Levi A. Garraway, Ensar Halilovic, Joel Greshock, Sébastien Jeay, Jens Wuerthner, Erick Morris, Dale Porter, Robert Schlegel, William R. Sellers, Matthew Zubrowski, Ali Farsidjani, Fred Harbinski, Samuel Ho, Angela Tam, Nicolas Ebel, Stéphane Ferretti, Thomas Horn |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22412681.v1 |
| Popis: |
From images to synergies (S1); Reproducibility of data from two screens (S2); Single agent responses and selectivity (S3); Screen-wide comparison of Caspase 3/7 activation and growth inhibition (S4); Heatmaps of growth inhibition and Capase 3/7 activation, and examples of broadly synergistic combinations targeting RAS/MAPK and/or PI3K/AKT pathways (S5); Combinations targeting RAS/MAPK and PI3K/AKT pathways at different nodes show similar efficacies (S6); Combinations involving RTKs (S7); Heatmaps of growth inhibition and Capase 3/7 activation, and examples of combinations targeting RAS/MAPK or PI3K/AKT pathways and other cellular processes (S8); Synergies of triple combination increase with synergies of underlying drug pairs (S9); Heatmap of synergies, growth inhibition, and Caspase 3/7 activation for triple combinations after hierarchical clustering (S10); Triple combinations targeting RAS/MAPK and PI3K/AKT pathways (S11); Triple combinations targeting RAS/MAPK and/or PI3K/AKT pathways and other cellular processes (S12); Combination targeting MDM2 and MEK in p53 wild-type models (S13); Sequential treatment of p53 wild-type lines with triple combination targeting MDM2, MEK, and BCL-2/-XL (S14); High order combinations to kill 'robust' cell lines (S15). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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