Phagocytes, Antibiotics, and Self-Limiting Bacterial Infections
| Autor: | Bruce R. Levin, Peter Ankomah, Fernando Baquero, Ingrid C. McCall |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.drug_class Phagocytosis 030106 microbiology Antibiotics Self limiting Biology Microbiology Treatment failure Mice 03 medical and health sciences Antibiotic resistance Immune system Virology Drug Resistance Bacterial High doses medicine Animals Heuristics Humans Phagocytes Treatment regimen Bacterial Infections Models Theoretical Anti-Bacterial Agents 030104 developmental biology Infectious Diseases Immunology |
| Zdroj: | Trends in Microbiology. 25:878-892 |
| ISSN: | 0966-842X |
| DOI: | 10.1016/j.tim.2017.07.005 |
| Popis: | Most antibiotic use in humans is to reduce the magnitude and term of morbidity of acute, community-acquired infections in immune competent patients, rather than to save lives. Thanks to phagocytic leucocytes and other host defenses, the vast majority of these infections are self-limiting. Nevertheless, there has been a negligible amount of consideration of the contribution of phagocytosis and other host defenses in the research for, and the design of, antibiotic treatment regimens, which hyper-emphasizes antibiotics as if they were the sole mechanism responsible for the clearance of infections. Here, we critically review this approach and its limitations. With the aid of a heuristic mathematical model, we postulate that if the rate of phagocytosis is great enough, for acute, normally self-limiting infections, then (i) antibiotics with different pharmacodynamic properties would be similarly effective, (ii) low doses of antibiotics can be as effective as high doses, and (iii) neither phenotypic nor inherited antibiotic resistance generated during therapy are likely to lead to treatment failure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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