Serum nitric oxide levels are depleted in depressed patients treated with electroconvulsive therapy
| Autor: | Almila Senat, Derya Ipekcioglu, Suat Yalcin, Baris Alpugan, Mehmet Cem Ilnem, Özlem Devrim Balaban, Ozge Canbek Atay, Murat İlhan Atagün, Ozcan Erel, Nesrin Karamustafalioglu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
business.industry
Depressive disorder medicine.medical_treatment Physiology Endogeny Serum samples electroconvulsive therapy Nitric oxide Psychiatry and Mental health chemistry.chemical_compound Electroconvulsive therapy chemistry nitric oxide medicine In patient Original Article Patient group Nitrite Neurotransmitter business |
| Zdroj: | Indian Journal of Psychiatry |
| ISSN: | 1998-3794 0019-5545 |
| Popis: | Background Nitric oxide (NO) is an endogenous substance which has several endocrine functions and may act as neurotransmitter in the brain. High levels of NO may provoke nitrosative stress. Aim It was aimed to examine serum levels of NO in patients with depressive episodes who were treated with electroconvulsive therapy (ECT) in this study. Methods The design was a case-control, follow-up study. Patients with depressive episodes (n = 23) and a healthy control group (n = 21) were enrolled. Three serum samples were obtained from the patient group (before ECT, after first and seventh sessions). NO, nitrite, and nitrate levels were examined. Statistical analysis Differences between groups were examined with t-test or Mann-Whitney U-test. Longitudinal data were evaluated with Panel Regression Analysis and Kruskal-Wallis Test. Results Serum levels of NO and nitrite decreased significantly after the seventh session of ECT administration compared to the baseline and first session. Nitrate levels did not differ between the assessments. Conclusions Reduction of the serum NO and nitrite levels might be a contributing factor for hypertension during the sessions. These findings are reflect the circulating NO levels. Further studies may dissect NO physiology in the brain in mental disorders and potential external effects. |
| Databáze: | OpenAIRE |
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