Effects of a continuous lipid infusion on glucose metabolism in critically ill patients
| Autor: | Yadh Khalfallah, J. Motin, B. Delafosse, J.P. Viale, G. Annat, Jean-Paul Riou, S. Tissot, Sylvie Normand |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Parenteral Nutrition Physiology Continuous infusion Endocrinology Diabetes and Metabolism Critical Illness Carbohydrate metabolism Excretion Oxygen Consumption Physiology (medical) Internal medicine Intensive care medicine Humans Infusions Intravenous Aged chemistry.chemical_classification Chemistry Critically ill Respiration Calorimetry Indirect Metabolism Carbon Dioxide Middle Aged Lipids Amino acid Endocrinology Glucose Female Lipid infusion |
| Zdroj: | The American journal of physiology. 269(4 Pt 1) |
| ISSN: | 0002-9513 |
| Popis: | The effects of lipid administration on carbohydrate oxidation rate remain controversial, particularly in critically ill patients. The aim of this study was to determine the effects of these patients of a continuous lipid infusion on glucose metabolism using indirect calorimetry and stable isotopes. We studied seven patients, mechanically ventilated, during two consecutive 24-h periods. Throughout the first period they received a continuous infusion of glucose (2 mg.kg-1.min-1) and amino acids. During the second period, in addition to the glucose, they received a continuous infusion of 1 mg.kg-1.min-1 of long-chain triglycerides emulsion. Substrate oxidation rates were calculated from pulmonary gas exchange and nitrogen excretion measurements. Glucose kinetic parameters were measured using primed constant infusions of [6,6-2H2]glucose and [1-13C]glucose. The lipid infusion did not modify the glucose metabolism parameters; 45% of the lipid supply was stored. |
| Databáze: | OpenAIRE |
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