Inhibition of Human Placental Microsomal Aromatase by Thyroid Hormone and Iodothyronine Derivatives
| Autor: | Yoshio Osawa, Keith Bullion |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Placenta Binding Competitive Endocrinology Non-competitive inhibition Pregnancy Microsomes Internal medicine medicine Humans Androstenedione Aromatase biology Aromatase Inhibitors Chemistry Thyroid Aromatization General Medicine Thyroxine medicine.anatomical_structure Biochemistry biology.protein Microsome Triiodothyronine Female Hormone |
| Zdroj: | Endocrine Research. 14:21-33 |
| ISSN: | 1532-4206 0743-5800 |
| DOI: | 10.1080/07435808809036337 |
| Popis: | The initial velocity kinetics of the effect of thyroid hormone and analogs on human placental microsomal aromatase were studied. Thyroxine and its propionic analog 3,5,3',5'-tetraiodothyropropionic acid show a competitive inhibition with an apparent Ki of 1.4 microM and 8.5 microM, respectively, towards androstenedione aromatization. 3,5,3'-Triiodothyronine with a Ki of 1.8 microM shows a decreased affinity compared to thyroxine. Two analogs, 3,5,3'-triiodothyropropionic acid and 3,5,3'-triiodothyroacetic acid appear to have negligible competition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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