Unifactorial inheritance of warfarin resistance in Rattus norvegicus from Denmark

Autor:	J. H. Greaves, P. B. Ayres
Rok vydání:	1977
Předmět:	Male Genetics Denmark Drug Resistance Warfarin Heterozygote advantage Locus (genetics) General Medicine Biology medicine.disease Major gene Rats Backcrossing Vitamin K deficiency medicine Animals Warfarin resistance Female Rodenticide medicine.symptom Crosses Genetic Genes Dominant medicine.drug
Zdroj:	Genetical Research. 29:215-222
ISSN:	1469-5073 0016-6723
Popis:	SUMMARYWild populations of the Norway rat, Rattus norvegicus, in Jutland have been known to be resistant to the anticoagulant rodenticide warfarin since 1962. The inheritance of the resistance was investigated in the F1, backcross and intercross. The results are consistent with the resistance being due to a major gene at the Rw locus. Resistant homozygotes, heterozygotes and susceptible homozygotes appeared to be distinguishable experimentally on the basis of differences in their susceptibility to vitamin K deficiency. The results are discussed in relation to previous studies of the inheritance of warfarin resistance in rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c5983d0fa676f833f04bf4eba667db https://doi.org/10.1017/s0016672300017298 Zobrazit plný text záznamu