Cardiovascular risk assessment in children and adolescents with congenital solitary kidneys
| Autor: | Eren Soyaltın, Cem Karadeniz, Belde Kasap-Demir, Onder Yavascan, Fatma Mutlubaş, Seçil Arslansoyu-Çamlar, Caner Alparslan, Tülay Demircan, Demet Alaygut |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Ambulatory blood pressure Adolescent Endocrinology Diabetes and Metabolism Blood Pressure Pulse Wave Analysis 030204 cardiovascular system & hematology Kidney 03 medical and health sciences chemistry.chemical_compound Vascular Stiffness 0302 clinical medicine Risk Factors Internal medicine Internal Medicine Humans Medicine 030212 general & internal medicine Child Pulse wave velocity Creatinine medicine.diagnostic_test business.industry Blood Pressure Monitoring Ambulatory medicine.disease Blood pressure chemistry Cardiovascular Diseases Heart Disease Risk Factors Hypertension Ambulatory Commentary cardiovascular system Arterial stiffness Cardiology Aortic stiffness Children and Adolescents Cardiology and Cardiovascular Medicine business Electrocardiography |
| Zdroj: | The Journal of Clinical Hypertension |
| Popis: | Patients with solitary kidneys (SKs) are at risk of hypertension (HT) and associated end-organ damage. The authors aimed to evaluate whether children with congenital SKs (CSKs) have higher office, ambulatory, or central blood pressure (BP), increased arterial stiffness or left ventricular mass index, or any risk for arrhythmia. With this purpose, patients with CSK and healthy controls being followed up between January 2018 and June 2019 were enrolled in the study. Demographic, biochemical, and office blood pressure (BP) data were recorded. Then, ambulatory blood pressure monitoring (ABPM) and measurements of central BP (cBP), pulse wave velocity (PWV), and augmentation index (AIx@75) were obtained. Ventricular repolarization parameters were acquired by 12-lead electrocardiography. Left ventricular mass index (LVMI) and abdominal aortic stiffness parameters including strain, pressure strain elastic modulus (Ep), and normalized Ep (Ep*) were calculated with echocardiographic measurements. Finally, 36 children with CSK and 36 healthy controls were included. Serum creatinine, uric acid, total cholesterol levels, ABPM parameters, cBP levels, and PWV values were significantly higher, and eGFR levels were significantly lower in the CSK group. VR parameters, abdominal aortic stiffness indices, and LVMI were similar between the groups. CSK increased the risk of HT in ABPM (HTABPM ) by 6 times. PWV was significantly correlated with Ep and Ep* in cases with CSK. Determination of cBP and PWV along with 24-hour ABPM would be a useful tool in children with CSK. |
| Databáze: | OpenAIRE |
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