Daidzein upregulates anti-aging protein Klotho and NaPi 2a cotransporter in a rat model of the andropause
| Autor: | Ivana Jarić, Vladimir Ajdžanović, Jasmina Živanović, Marija Mojić, Verica Milošević, Branka Šošić-Jurjević, Branko Filipović, Marko Miler |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Phytoestrogens Urine Sodium-Phosphate Cotransporter Proteins Type IIa Andropause Klotho 03 medical and health sciences chemistry.chemical_compound Internal medicine Sodium phosphate cotransporter 2a medicine Pi Animals Rats Wistar Klotho Proteins Glucuronidase 2. Zero hunger Kidney Creatinine Chemistry Daidzein Parathyroid gland General Medicine Isoflavones Rats Up-Regulation 3. Good health Disease Models Animal 030104 developmental biology medicine.anatomical_structure Endocrinology Gene Expression Regulation Rat 030101 anatomy & morphology Anatomy Orchiectomy Homeostasis Developmental Biology |
| Zdroj: | Annals of Anatomy = Anatomischer Anzeiger |
| Popis: | In a rat model of the andropause we aimed to examine the influence of daidzein, soy isoflavone, on the structure and function of parathyroid glands (PTG) and the expression levels of some of the crucial regulators of Ca2+ and Pi homeostasis in the kidney, and to compare these effects with the effects of estradiol, serving as a positive control. Middle-aged (16-month-old) male Wistar rats were divided into the following groups: sham-operated (SO), orchidectomized (Orx), orchidectomized and estradiol-treated (Orx+E; 0.625mg/kg b.w./day, s.c.) as well as orchidectomized and daidzein-treated (Orx+D; 30mg/kg b.w./day, s.c.) group. Every treated group had a corresponding control group. PTH serum concentration was decreased in Orx+E and Orx+D groups by 10% and 21% (p |
| Databáze: | OpenAIRE |
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