Evolution in the sensitivity of quantitative HIV-1 viral load tests
| Autor: | Bryan Cobb, Regis A. Vilchez, Tri D. Do, Jeffrey Vaks |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
business.industry
Human immunodeficiency virus (HIV) virus diseases Guidelines as Topic HIV Infections Context (language use) Viral Load Real-Time Polymerase Chain Reaction Molecular diagnostics medicine.disease_cause Sensitivity and Specificity Virology Virus Infectious Diseases Real-time polymerase chain reaction HIV-1 TaqMan Humans RNA Viral Medicine In patient business Viral load |
| Zdroj: | Journal of Clinical Virology. 52:S77-S82 |
| ISSN: | 1386-6532 |
| Popis: | Significant advancements in molecular diagnostics have been made since the inception and application of PCR-based technologies in clinical diagnostic laboratories and the management of HIV-1 infected patients. More recently, real-time PCR has improved the overall performance of assays used for detecting and quantifying HIV-1 RNA viral load in patients undergoing antiretroviral treatment. The effects of these changes and the interpretations of the HIV-1 viral load results are discussed in this review in the context of the different assays used, the viral dynamics of the HIV-1 virus, and the recent changes to HIV-1 treatment guidelines. |
| Databáze: | OpenAIRE |
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