Does pallidal neuromodulation influence cognitive decline in Huntington’s disease?

Autor: Valérie Macioce, Philippe Coubes, Gaëtan Poulen, Fabienne Cyprien, Laura Cif, Victoria Gonzalez, Emily Sanrey, Emilie Chan Seng
Přispěvatelé: Service de Neurochirurgie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Gui de Chauliac [Montpellier], Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Pediatrics
medicine.medical_specialty
congenital
hereditary
and neonatal diseases and abnormalities
MESH: Globus Pallidus
Longitudinal follow-up
Deep Brain Stimulation
Cognitive decline
Disease
Globus Pallidus
MESH: Cognitive Dysfunction
03 medical and health sciences
0302 clinical medicine
Huntington's disease
Chorea
Medicine
Humans
Cognitive Dysfunction
030212 general & internal medicine
Neuropsychological assessment
MESH: Chorea
MESH: Humans
medicine.diagnostic_test
business.industry
Cognition
medicine.disease
Neuromodulation (medicine)
MESH: Huntington Disease
3. Good health
Huntington Disease
Neurology
Continuous electrical neuromodulation
Cohort
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Neurology (clinical)
medicine.symptom
MESH: Deep Brain Stimulation
business
030217 neurology & neurosurgery
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Huntington’s disease
Zdroj: Journal of Neurology
Journal of Neurology, Springer Verlag, 2021, 268 (2), pp.613-622. ⟨10.1007/s00415-020-10206-w⟩
ISSN: 0340-5354
1432-1459
Popis: International audience; Objective: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder associated with motor, psychiatric and cognitive deterioration over time. To date, Continuous Electrical Neuromodulation (CEN) of the globus pallidus internus (GPi) has been reported to improve chorea but little is known about cognitive progression in these patients. We propose to examine CEN impact on expected cognitive decline throughout long-term neuropsychological assessment of a cohort of HD patients.Method: 13 consecutive HD patients underwent GPi neuromodulation between January 2008 and February 2019. Over a 5-year follow-up period, they received systematic pre- and post-operative assessment according to the existing protocol in our unit. The main outcome measure was the total score obtained on the Mattis Dementia Rating Scale (MDRS) as an indicator of global cognitive function.Results: Chorea decreased in all patients postoperatively with a mean improvement of 56% despite disease progression over time, according to previous studies. Moreover we found that the global cognitive profile of HD patients treated with CEN was stable during the first 3 years of treatment.Conclusion: We report an unexpected positive influence of GPi continuous electrical neuromodulation on the progression of global cognitive functioning in operated HD patients. This is the most important group of patients treated with this method to our knowledge whatever the sample size remains small. This result provides promising evidence of GPi-CEN efficacy not only in reducing chorea, but also in delaying cognitive decline in HD patients operated at an early stage of the disease.
Databáze: OpenAIRE
Externí odkaz: