Effects of intravenous infusion of lidocaine and dexmedetomidine on inhibiting cough during the tracheal extubation period after thyroid surgery
| Autor: | Xia Ju, Sheng-Hong Hu, Shengbin Wang, Yuan-Hai Li, Si-Qi Xu, Li Ma |
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| Rok vydání: | 2019 |
| Předmět: |
Bradycardia
Adult Male medicine.medical_specialty Lidocaine genetic structures Visual analogue scale medicine.medical_treatment Thyroid Gland Hemodynamics Pilot Projects lcsh:RD78.3-87.3 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Heart rate medicine Humans Hypnotics and Sedatives Prospective Studies Dexmedetomidine Anesthetics Local Infusions Intravenous Saline Pain Measurement business.industry 030208 emergency & critical care medicine Middle Aged Thyroid surgery Surgery Anesthesiology and Pain Medicine Blood pressure Cough lcsh:Anesthesiology Anesthesia Recovery Period Airway Extubation Female medicine.symptom business medicine.drug Research Article |
| Zdroj: | BMC Anesthesiology BMC Anesthesiology, Vol 19, Iss 1, Pp 1-8 (2019) |
| Popis: | Background Intravenous lidocaine and dexmedetomidine treatments have been proposed as methods for inhibiting cough. We compared the efficacy of intravenous lidocaine and dexmedetomidine treatments on inhibiting cough during the tracheal extubation period after thyroid surgery. Methods One hundred eighty patients undergoing thyroid surgeries were randomly allocated to the LIDO group (received lidocaine 1.5 mg/kg loading, 1.5 mg/kg/h infusion), the DEX group (received dexmedetomidine 0.5 μg/kg loading, 0.4 μg/kg/h infusion) and the CON group (received saline), with 60 cases in each group. The primary outcomes of cough were recorded. Secondary outcomes included hemodynamic variables, awareness time, volume of drainage, the postoperative visual analogue scale and adverse effects were recorded. Results The incidence of cough were significantly lower in the LIDO group (28.3%) and the DEX group (31.7%) than that in the CON group (66.7%) (P = 0.000). Additionally, both moderate and severe cough were significantly lower in the LIDO group (13.3%) and the DEX group (13.4%) than these in the CON group (43.4%) (P |
| Databáze: | OpenAIRE |
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