Effects of dexamethasone and stressful stimuli on hypothalamic electrical activity in rats with diencephalic islands
| Autor: | J.I. Kitay, J.G. Ondo |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
Vasopressin medicine.medical_specialty Vasopressins Endocrinology Diabetes and Metabolism Period (gene) Hypothalamus Biology Electroencephalography Dexamethasone Cerebral Ventricles Stereotaxic Techniques Cellular and Molecular Neuroscience Basal (phylogenetics) chemistry.chemical_compound Endocrinology Adrenocorticotropic Hormone Stress Physiological Internal medicine medicine Animals Diencephalon Neurons medicine.diagnostic_test Endocrine and Autonomic Systems Rats Electrophysiology nervous system chemistry Depression Chemical Thalamic Nuclei Histamine medicine.drug Hormone |
| Zdroj: | Neuroendocrinology. 9(4) |
| ISSN: | 0028-3835 |
| Popis: | Electrical activity in the hypothalamus was recorded following dexamethasone administration to intact and diencephalic-island animals. In intact animals, dexamethasone produced an equal number of increases or decreases in unit resting firing frequencies. At least half of these rate changes were accompanied by alterations in EEG. Of the units tested in the basal hypothalamus of diencephalic-island animals, 50 % were inhibited by dexamethasone within a 10–15 minute period, 9% showed an increased firing rate, and the remainder were unresponsive. The results indicate a direct effect of the hormone on neurons in the isolated basal hypothalamus. Hypothalamic electrical activity was also recorded following the administration of vasopressin and histamine, two agents known to activate the adrenocortical system. The compounds uniformly produced rapid inhibition in unit firing in both intact and diencephalic-island animals. Thus, compounds with opposite actions on ACTH secretion, i.e., dexamethasone or vasopressin and histamine, produce the same inhibitory effect on the firing rate of hypothalamic neurons. |
| Databáze: | OpenAIRE |
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