Serum leptin level in breast cancer
| Autor: | Koprivčić, Ivan, Marjanović, Ksenija, Matić, Anita, Tolušić Levak, Maja, Lovrić, Ivan, Pauzar, Biljana, Erić, Ivan, Wertheimer, Vjekoslav |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Acta clinica Croatica Volume 61. Issue 1. |
| ISSN: | 0353-9466 1333-9451 |
| Popis: | Leptin is a polypeptide which is mostly produced in white fat tissue and is an important proinflammatory, proangiogenic, proinvasive and mitotic factor. There is ever more evidence suggesting the key role of leptin in the occurrence of breast cancer. The aim of the study was to investigate serum leptin levels in patients with benign breast tumors, as well as in various breast cancer phenotypes, taking into account leptin levels connected to menopausal status and body mass index (BMI). The study included 97 patients having their breast tumor surgically removed. Serum leptin level was determined by ELISA method in all study patients. Study results showed that significantly more women, regardless of having malignant or benign tumors, were postmenopausal and had a significantly higher level of leptin compared to the premenopausal group. The highest level of leptin was recorded in the group of postmenopausal obese women compared to other postmenopausal women but also compared to premenopausal women. According to BMI alone, obese women had a significantly higher level of leptin regardless of the type of tumor. The most significant differences in leptin levels observed through BMI were found in the Luminal B1 group. In conclusion, serum leptin level was shown to be a good diagnostic parameter suggesting a higher possibility of breast cancer development. Leptin je polipeptid koji se uglavnom proizvodi u bijelom masnom tkivu te predstavlja važan proupalni, proangiogeni, proinvazivni i mitotički čimbenik. Sve je više dokaza koji ukazuju na ključnu ulogu leptina u nastanku tumora dojke. Istraživali smo serumsku razinu leptina u bolesnica s benignim tumorima dojke, kao i kod različitih fenotipova malignih tumora dojke te ovisnost razine leptina o reproduktivnom statusu i indeksu tjelesne mase (ITM). Istraživanje je obuhvatilo 97 bolesnica kojima je tumor uklonjen kirurškim zahvatom. Serumska koncentracija leptina utvrđena je metodom ELISA u svih bolesnica uključenih u istraživanje. Znatno više žena, bez obzira na to jesu li imale zloćudni ili dobroćudni tumor, bilo je u postmenopauzi te su imale značajno više razine leptina u usporedbi s premenopauzalnim skupinama. Najviša razina leptina utvrđena je kod pretilih žena u postmenopauzi u usporedbi s drugim ženama u postmenopauzi, ali i u usporedbi sa ženama u premenopauzi. Prema ITM, pretile ispitanice su imale značajno više razine leptina bez obzira na vrstu tumora. Najznačajnije razlike u razinama leptina, promatrane kroz ITM, utvrđene se u skupini Luminal B1. Razina leptina u serumu je dobar dijagnostički parametar koji govori u prilog većoj predispoziciji za nastanak karcinoma dojke. |
| Databáze: | OpenAIRE |
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