Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice
| Autor: | Guannan Wang, Nanjoo Suh, Isao Matsuura, Mou-Tuan Huang, Fang Liu, Tanima Kundu-Roy, Nicola Barnard, Yong Lin, Zhengxue Liu, Xiao-Fan Wang, You Rong Lou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Heterozygote Mice 129 Strain Carcinogenesis 9 10-Dimethyl-1 2-benzanthracene DMBA Adenocarcinoma medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound Mice Breast cancer breast cancer medicine Animals Smad3 Protein skin and connective tissue diseases Carcinogen Mice Knockout Mammary tumor integumentary system business.industry 7 12-Dimethylbenz[a]anthracene Tumor Suppressor Proteins Mammary Neoplasms Experimental medicine.disease 3. Good health Mice Inbred C57BL 030104 developmental biology Oncology chemistry TGF-ß Cell culture Cancer research Carcinogens Female biological phenomena cell phenomena and immunity business Research Paper Smad3 |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Previous studies based on cell culture and xenograft animal models suggest that Smad3 has tumor suppressor function for breast cancer during early stages of tumorigenesis. In this report, we show that DMBA (7,12-dimethylbenz[a]anthracene), a chemical carcinogen, induces mammary tumor formation at a significantly higher frequency in the Smad3 heterozygous mice than in the Smad3 wild type mice. This is the first genetic evidence showing that Smad3 inhibits mammary tumor formation in a mouse model. Our findings support the notion that Smad3 has important tumor suppressor function for breast cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|