Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 5. 9-Deazahypoxanthines
| Autor: | Pooran Chand, John A. Montgomery, Ved P. Pathak, Shri Niwas |
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| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
biology Bicyclic molecule Stereochemistry Purine nucleoside phosphorylase Biological activity Crystallography X-Ray chemistry.chemical_compound Glycogen phosphorylase Enzyme Purine-Nucleoside Phosphorylase chemistry Biochemistry Enzyme inhibitor Drug Design Hypoxanthines Drug Discovery Glycosyltransferase Lactam biology.protein Molecular Medicine |
| Zdroj: | Journal of Medicinal Chemistry. 37:2477-2480 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | The synthesis and evaluation as inhibitors of purine nucleoside phosphorylase of six 9-deazahypoxanthines (2a-f) are reported. In contrast to reports in the literature of other hypoxanthine-guanine analog pairs, these inhibitors (2a-f) are equipotent with the corresponding 9-deazaguanines. |
| Databáze: | OpenAIRE |
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