Serum hepcidin levels are related to serum markers for iron metabolism and fibrosis stage in patients with chronic hepatitis B: A cross-sectional study
| Autor: | Hakan Çam, Nimet Yılmaz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Turkey Iron Elevated transferrin saturation Gastroenterology 03 medical and health sciences Liver disease 0302 clinical medicine Hepatitis B Chronic Hepcidins Liver Function Tests Fibrosis Hepcidin Internal medicine medicine Humans Clinical significance Correlation of Data medicine.diagnostic_test biology business.industry Patient Acuity Transferrin Middle Aged medicine.disease Cross-Sectional Studies Liver 030220 oncology & carcinogenesis Liver biopsy Ferritins Serum iron biology.protein 030211 gastroenterology & hepatology Female Liver function tests business Biomarkers |
| Zdroj: | Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology. 21(2) |
| ISSN: | 2090-2387 |
| Popis: | The clinical significance of serum parameters of iron metabolism and hepcidin in liver disease remains unknown. Therefore, this study aimed to evaluate the association of serum hepcidin levels with fibrosis stage and serum iron parameters in patients with chronic hepatitis B (CHB).This cross-sectional study included 126 treatment-naïve patients with CHB (median age, 39.0 years; 64.3% males) who were positive for hepatitis B surface antigen and 23 healthy controls (median age, 33.0 years; 52.2% males). Data on patient demographics, serum hepcidin levels, liver function tests and serum iron parameters and liver biopsy findings including fibrosis grade, histological activity index (HAI) and liver iron level were recorded.The median (minimum-maximum) serum hepcidin levels were significantly lower in the CHB group than in the control group [71.2 (13.3-672.7) vs. 657.5 (201.7-2714.2) pg/mL, p 0.001]. Higher fibrosis stage was associated with higher transferrin saturation (p = 0.029), serum ferritin level (p 0.001) and viral load (p 0.001). Fibrosis stage and HAI were positively correlated with ferritin (r = 0.407, p 0.001 and r = 0.415, p 0.001, respectively) and transferrin saturation (r = 0.219, p = 0.026 and r = 0.290, p = 0.003, respectively) levels, whereas hepcidin level was negatively correlated with fibrosis stage (r = -0.175, p = 0.051), viral load (r = -0.209, p = 0.020) and ferritin level (r = -0.244, p = 0.006) level. There were no significant differences in serum iron level, total iron binding capacity and liver iron level among patients with different stages of fibrosis.Reduced hepcidin levels and elevated transferrin saturation and ferritin levels are linked to fibrosis severity and HAI in patients with CHB. |
| Databáze: | OpenAIRE |
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