Antimicrobial Properties of Perfusate Fluid After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CS-HIPEC) with Mitomycin C
| Autor: | Brian G. Gentry, Danielle McKay, Jan Franko, Krystle N. Lange |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Staphylococcus aureus medicine.medical_treatment Mitomycin 030106 microbiology medicine.disease_cause Gastroenterology Agar plate 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Escherichia coli Humans Infusions Parenteral Prospective Studies Saline Peritoneal Neoplasms Chemotherapy Antibiotics Antineoplastic business.industry Mitomycin C Cytoreduction Surgical Procedures Hyperthermia Induced Antimicrobial Prognosis Combined Modality Therapy Anti-Bacterial Agents Perfusion Oncology chemistry 030220 oncology & carcinogenesis Anesthesia Chemotherapy Cancer Regional Perfusion Surgery Hyperthermic intraperitoneal chemotherapy Growth inhibition business Follow-Up Studies |
| Zdroj: | Annals of surgical oncology. 24(13) |
| ISSN: | 1534-4681 |
| Popis: | Infectious postoperative complications often delay systemic chemotherapy after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CS-HIPEC). Because the authors have empirically observed fewer incisional infectious complications than expected after CS-HIPEC with mitomycin C (MMC), they investigated the antimicrobial properties of HIPEC perfusate fluid. This study prospectively measured in vitro bacterial growth inhibition by HIPEC perfusate (n = 18). After 10 µL of perfusate had been plated on agar plate inoculated by standard strains of either Escherichia coli (strain 25922) or Staphylococcus aureus (strain 25923), it was incubated at 37 °C for 24 h. Antimicrobial activity evidenced by a zone of complete growth inhibition was measured in millimeters. These were compared against growth inhibition produced by control groups represented by MMC solution in normal saline (MMC concentrations of 2, 4, 6, 8, and 8.75 µg/mL), 7 per group. Bacterial inhibition by HIPEC perfusate was stronger against E. coli than against S. aureus (13.1 ± 6.8 vs 8.3 ± 7.7 mm; p = 0.005). No E. coli inhibition was observed for MMC saline in concentrations of 2 through 8 µg/mL (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink