Low Serum Leptin Predicts Mortality in Patients with Chronic Kidney Disease Stage 5*
| Autor: | Alexandra Scholze, Walter Zidek, Martin Tepel, Dirk Rattensperger |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Medicine (miscellaneous) Adipose tissue Gastroenterology Endocrinology Renal Dialysis Internal medicine medicine Humans Prospective cohort study Survival analysis Aged Aged 80 and over Nutrition and Dietetics business.industry digestive oral and skin physiology Middle Aged Prognosis medicine.disease Survival Analysis Confidence interval Relative risk Kidney Failure Chronic Biological Markers Female Hemodialysis business hormones hormone substitutes and hormone antagonists Biomarkers Follow-Up Studies Kidney disease |
| Zdroj: | Scholze, A, Rattensperger, D, Zidek, W & Tepel, M 2007, ' Low serum leptin predicts mortality in patients with chronic kidney disease stage 5 ', Obesity, vol. 15, no. 6, pp. 1617-22 . https://doi.org/10.1038/oby.2007.191 |
| ISSN: | 1930-739X 1930-7381 |
| Popis: | Objective: Leptin, secreted from adipose tissue, regulates food intake, energy expenditure, and immune function. It is unknown whether leptin predicts mortality in patients with chronic kidney disease stage 5 on hemodialysis therapy. Research Methods and Procedures: We performed a prospective cohort study of 71 patients with chronic kidney disease stage 5 in an outpatient hemodialysis center. Subjects were recruited in June 1998 and followed for 83 months. Survival was compared by the Kaplan-Meier method. Results: After 83 months of follow-up, 48 patients (68%) had died. Serum leptin concentrations at study entry were lower among all deceased patients compared with those patients who survived (5.2 ± 9.0 μg/L; n = 48; vs. 7.7 ± 7.8 μg/L; n = 23; p = 0.005). Baseline serum leptin concentrations were significantly lower in patients who died from cardiovascular diseases (4.7 ± 9.4 μg/L, n = 32) or infections (4.0 ± 2.7 μg/L; n = 10; each p < 0.05), but not cancer (9.4 ± 7.9 μg/L; n = 6), than in survivors (7.7 ± 7.8 μg/L; n = 23; p = 0.003). The relative risk for mortality in patients with serum leptin concentrations below the median ( |
| Databáze: | OpenAIRE |
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