Fluphenazine-induced parkinsonism in the baboon: pharmacological and metabolic studies
| Autor: | D.D. Devine, J. Dreyfuss, E.C. Schreiber, B.F. Roberts, B. Beer |
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| Rok vydání: | 1972 |
| Předmět: |
Drug
Fluphenazine Metabolite media_common.quotation_subject Pharmacology Cellular and Molecular Neuroscience chemistry.chemical_compound Feces Basal Ganglia Diseases Oral administration biology.animal medicine Animals Parkinson Disease Secondary media_common Benztropine Trihexyphenidyl Hydrochloride Carbon Isotopes biology business.industry Parkinsonism Parkinson Disease Haplorhini medicine.disease Trihexyphenidyl chemistry Benztropine Mesylate Female Chromatography Thin Layer business medicine.drug Baboon Half-Life Papio |
| Zdroj: | Neuropharmacology. 11(2) |
| ISSN: | 0028-3908 |
| Popis: | Extrapyramidal signs were produced in baboons following the oral administration of 1.5–5 mg/kg per day of fluphenazine dihydrochloride. The drug-induced extrapyramidal signs included tremors at rest or in motion, motor retardation, masque facies, rigidity, and salivation. Administration of the anti-parkinson agents benztropine mesylate or trihexyphenidyl hydrochloride was ineffective in reversing the extrapyramidal signs when these agents were given together with fluphenazine. 7-Hydroxyfluphenazine, a metabolite of fluphenazine in the baboon, was at least 500 times less active than fluphenazine in producing depression and did not produce extrapyramidal signs. Metabolic studies with nuphenazine- 14 C in the baboon indicated that the biological disposition of the drug resembles that seen previously in the rhesus monkey. The plasma half-life for the elimination of fluphenazine- 14 C, its metabolites, or both, agrees roughly with the length of time required for extrapyramidal signs to disappear after withdrawal of the drug. |
| Databáze: | OpenAIRE |
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