Estrogenic xenobiotics affect the intracellular activation signal in mitogen-induced human peripheral blood lymphocytes : immunotoxicological impact
| Autor: | Fujio Kayama, Masahiko Okuma, Wataru Fujii, Hiroyuki Furuya, Michitake Kazuno, Yoshihide Suwa, Kou Sakabe, Toshiya Yamaguchi, Takahiko Yoshida, Kerin L Fresa |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
DNA Replication Lymphocyte Immunology chemical and pharmacologic phenomena Lymphocyte proliferation Biology Lymphocyte Activation Xenobiotics Estradiol Congeners medicine Humans Lymphocytes Cells Cultured Protein Kinase C Protein kinase C Pharmacology Estradiol DNA synthesis Cell growth hemic and immune systems Cell biology medicine.anatomical_structure Biochemistry Mitogen-activated protein kinase biology.protein Female Signal transduction Intracellular Signal Transduction |
| Zdroj: | International Journal of Immunopharmacology. 20:205-212 |
| ISSN: | 0192-0561 |
| DOI: | 10.1016/s0192-0561(98)00030-7 |
| Popis: | The present study was an attempt to elucidate the effect of estrogenic xenobiotics on the proliferation of mitogen-stimulated human peripheral blood lymphocyte (PBL). Our findings follow : (a) the proliferation of PBL in response to phytohemagglutinin (PHA) was mediated by protein kinase C activity, but estrogenic xenobiotics had a strong inhibitory effect on protein kinase C activity of PHA-stimulated PBL ; (b) cytoplasmic extracts from PHA-stimulated PBL greatly activated DNA replication, but estrogenic xenobiotics had a strong inhibitory effect on these activities. The results suggest that the cytoplasmic signal-generating system in mitogen-treated PBL is inhibited by estrogenic xenobiotics, and that the defect occurs at all stages in the sequence of events leading to DNA synthesis and cell proliferation. |
| Databáze: | OpenAIRE |
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