Associations between daily alcohol consumption and systemic lupus erythematosus-related cytokines and chemokines among US female nurses without SLE

Autor:	Judith A. James, Jeffrey A. Sparks, Elizabeth W. Karlson, Jill Hahn, Cianna Leatherwood, Laura D. Kubzansky, Bing Lu, Candace H. Feldman, Susan Malspeis, Karen H. Costenbader, Melissa E. Munroe, Andrea L. Roberts, Xinyi Liu
Rok vydání:	2020
Předmět:	Adult 0301 basic medicine medicine.medical_specialty Chemokine Alcohol Drinking medicine.medical_treatment Nurses Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Rheumatology Epidemiology medicine Humans Lupus Erythematosus Systemic Risk factor 030203 arthritis & rheumatology Systemic lupus erythematosus biology business.industry Middle Aged medicine.disease United States Black or African American 030104 developmental biology Cytokine Antibodies Antinuclear Case-Control Studies Immunology Linear Models biology.protein Cytokines Biomarker (medicine) Female Chemokines business Alcohol consumption
Zdroj:	Lupus
ISSN:	1477-0962 0961-2033
DOI:	10.1177/0961203320929427
Popis:	Objectives Moderate alcohol consumption has been associated with decreased systemic lupus erythematosus risk, but the biologic basis for this association is unknown. We aimed to determine whether moderate alcohol consumption was associated with lower concentrations of systemic lupus erythematosus-associated chemokines/cytokines in an ongoing cohort of female nurses without systemic lupus erythematosus, and whether the association was modified by the presence of systemic lupus erythematosus-related autoantibodies. Methods About 25% of participants from the Nurses’ Health Study ( n = 121,700 women) and Nurses’ Health Study 2 ( n = 116,429) donated a blood sample; of these, 1177 women were without systemic lupus erythematosus at time of donation. Cumulative average and current (within 4 years) intakes of beer, wine or liquor were assessed from pre-blood draw questionnaires. Chemokine/cytokine concentrations (stem cell factor, B-lymphocyte stimulator, interferon-inducible protein-10, interferon-alpha, interleukin-10) and antibodies against dsDNA and extractable nuclear antigens were obtained using enzyme-linked immunosorbent assays. Antinuclear antibodies were detected by indirect immunofluorescence on HEp-2 cells. Results At blood draw, the women’s mean age was 56 years and 22% were antinuclear antibody positive; 36% were African-American. About half (46%) reported consuming 0–5 g/day of alcohol. Stem cell factor levels were 0.5% lower ( p 5 g/day had mean stem cell factor levels 7% lower ( p = 0.002) than non-drinkers. Other cytokines were not significantly associated with alcohol intake. Autoantibody status did not modify observed associations. Conclusion In this study of female nurses, moderate alcohol consumption was associated with lower stem cell factor levels, suggesting a plausible mechanism through which alcohol may lower systemic lupus erythematosus risk might be by decreasing circulating stem cell factor.
Databáze:	OpenAIRE
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